Autor(es):Mostrar menos -

Pinto, Ana jessica ; Meireles, Kamila ; Pecanha, Tiago ; Mazzolani, Bruna caruso ; Smaira, Fabiana infante ; Rezende, Diego ; Benatti, Fabiana braga ; Ribeiro, Ana Cristina De Medeiros ; Pinto, Ana Lucia De Sa ; Lima, Fernanda rodrigues ; Roschel, Hamilton ; Gualano, Bruno

• Tipo de documento: Artigo Científico
• Fonte: MEDICINE AND SCIENCE IN SPORTS AND EXERCISE; v. 57, n. 1, p. 10-pg., 2025-01-01.

Resumo

PurposeWe investigated the effects of a 4-month intervention targeting sedentary behavior on sedentary time and physical activity level, clinical parameters, cardiometabolic risk factors, inflammatory markers, and health-related quality of life in postmenopausal women with rheumatoid arthritis.MethodsThis was a 4-month, parallel-group, randomized controlled trial (ClinicalTrials.gov identifier: NCT03186924). One hundred and three postmenopausal rheumatoid arthritis patients were randomized (1:1) to either a newly developed intervention targeting sedentary behavior (Take a STAND for Health [TS4H]) or standard of care (SOC). Sedentary behavior (primary outcome) and physical activity levels, clinical parameters, anthropometric parameters and body composition, blood samples and oral glucose tolerance test, blood pressure, muscle function, and health-related quality of life were assessed at baseline (Pre) and after 4 months (Post). Between- and within-group differences were tested using linear mixed models following the intention-to-treat principle.ResultsTotal sedentary time, time in prolonged sitting bouts, standing, and stepping did not change in either group (all P >= 0.337). No significant between- and within-group differences were detected for any of the clinical parameters, markers of cardiometabolic health and inflammation, and health-related quality of life variables (all P >= 0.136). Among responders in TS4H group (those who reduced sedentary time by >= 30 min<middle dot>d-1), Pre to Post IL-10 concentrations tended to reduce (group-time: P = 0.086; estimated mean difference [EMD]: -12.0 pg<middle dot>mL-1 [-23.5 to -0.6], P = 0.037) and general health (group-time: P = 0.047; EMD: 10.9 A.U. [-1.1 to 22.9], P = 0.086) and overall physical health tended to improve (group-time: P = 0.067; EMD: 7.9 A.U. [-0.9 to 16.6], P = 0.089).ConclusionsTS4H did not change sedentary behavior, physical activity levels, clinical, cardiometabolic, inflammatory, or health-related quality of life outcomes. However, TS4H tended to reduce IL-10 levels and improve health-related quality of life in responders. (AU)

• Processo FAPESP: 16/23319-0 - Disfunção autonômica cardiovascular em pacientes com artrite reumatoide: caracterização, associações com a doença e efeitos da interrupção do tempo sedentário
• Beneficiário: Tiago Peçanha de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/13552-2 - Reduzindo tempo sedentário em populações clínicas: o estudo take a stand for health
• Beneficiário: Bruno Gualano
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/19418-9 - Efeitos agudos e crônicos da redução do tempo sedentário em pacientes com artrite reumatoide: o estudo Take a stand for health
• Beneficiário: Ana Jéssica Pinto
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 15/26937-4 - Estudos sobre (in)atividade física em pacientes com artrite reumatóide: caracterização, associações com a doença e efeitos da interrupção do tempo sedentário
• Beneficiário: Ana Jéssica Pinto
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 17/17837-1 - Comportamento sedentário, (in)atividade física e consumo alimentar em pacientes com artrite reumatóide: associações com a doença e com fatores de riscos cardiometabólicos
• Beneficiário: Fabiana Infante Smaira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica