Autoantibody clusters in childhood-onset systemic lupus erythematosus: Insights from a multicenter study with 912 patients

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Trindade, Vitor C. ; Bonfa, Eloisa ; Sakamoto, Ana P. ; Terreri, Maria T. ; Aikawa, Nadia E. ; Fiorot, Fernanda J. ; Pitta, Ana C. ; Balbi, Verena A. ; Rabelo Jr, Carlos N. ; Silva, Marco F. ; Islabao, Aline G. ; Novak, Glaucia, V ; Kozu, Katia T. ; Buscatti, Izabel M. ; Campos, Lucia M. ; Sallum, Adriana M. E. ; Assad, Ana P. ; Magalhaes, Claudia S. ; Marini, Roberto ; Fonseca, Adriana R. ; Sztajnbok, Flavio R. ; Santos, Maria C. ; Bica, Blanca E. ; Sena, Evaldo G. ; Moraes, Ana J. ; Robazzi, Teresa C. ; Spelling, Paulo F. ; Scheibel, Iloite M. ; Cavalcanti, Andre S. ; Matos, Erica N. ; Guimaraes, Luciano J. ; Santos, Flavia P. ; Carvalho, Luciana M. ; Carneiro-Sampaio, Magda ; Ferraro, Alexandre A. ; Silva, Clovis A.

• Tipo de documento: Artigo Científico
• Fonte: Lupus; v. N/A, p. 8-pg., 2025-01-27.

Resumo

Objective: To identify clusters of autoantibodies in a large cSLE population and to verify possible associations between different autoantibody clusters and the following variables: demographic data, cumulative clinical and laboratory manifestations, disease activity, cumulative damage and mortality. Methods: A cross-sectional study was performed in 27 Pediatric Rheumatology University centers, including 912 cSLE patients. The frequencies of seven selected autoantibodies (anti-dsDNA, anti-Ro/SSA, anti-La/SSB, anti-Sm, anti-RNP, aCL IgM and/or IgG and LA) were used for cluster analysis using the K-means method. Results: Four distinctive antibody clusters were identified. Cluster 1 (n = 322; 35.31%) was characterized by anti-dsDNA (61.18%), low frequency of antiphospholipid antibodies (<10%), and lower frequency of cutaneous, articular manifestation (p < 0.05) and hypocomplementemia (p < 0.001) compared to the other groups. Cluster 2 (n = 158; 17.32%) comprised anti-dsDNA (93.04%), aCL (87.34%) and LA (39.87%) and higher frequencies of thrombocytopenia (p = 0.006) and antiphospholipid syndrome (p < 0.001) than the other clusters. Cluster 3 (n = 177; 19.41%) was characterized by anti-dsDNA (81.36%), anti-Sm (100%) and anti-RNP (44.63%) antibodies, as well as a higher frequency of proteinuria compared to cluster 4 (58.15% vs 56.13% vs 64.00% vs 49.80%, p = 0.031). Cluster 4 (n = 255; 27.96%) consisted of all 7 autoantibodies, with predominance of anti-dsDNA (72.55%), anti-Ro/SSA (89.8%) and anti-La/SSB (45.88%), with no specific clinical pattern, except by higher pulmonary damage (p = 0.017). Conclusions:Our study suggests that, within the context of cSLE, the coexistence of anti-dsDNA with antiphospholipid autoantibodies is linked to an elevated incidence of antiphospholipid syndrome. This association does not coincide with a proportionate increase in the occurrence of nephritis. Conversely, the cluster of anti-dsDNA with anti-Ro/SSA and anti-La/SSB antibodies was associated with pulmonary damage, requiring close surveillance. (AU)

• Processo FAPESP: 22/12925-8 - Estratégias de prevenção de infecções, mecanismos e fatores que influenciam a resposta às intervenções em pacientes com doenças reumáticas autoimunes
• Beneficiário: Eloisa Silva Dutra de Oliveira Bonfá
• Modalidade de apoio: Auxílio à Pesquisa - Temático