Breaking barriers: The potential of nanosystems in antituberculosis therapy

Autor(es)

Canales, Christian S. Carnero ; Cazorla, Jessica Ingrid Marquez ; Cazorla, Renzo Marianito Marquez ; Roque-Borda, Cesar Augusto ; Polinario, Giulia ; Banda, Rufo A. Figueroa ; Sabio, Rafael Miguel ; Chorilli, Marlus ; Santos, Helder A. ; Pavan, Fernando Rogerio

• Tipo de documento: Artigo Científico
• Fonte: BIOACTIVE MATERIALS; v. 39, p. 29-pg., 2024-09-01.

Resumo

Tuberculosis (TB), caused by Mycobacterium tuberculosis, continues to pose a significant threat to global health. The resilience of TB is amplified by a myriad of physical, biological, and biopharmaceutical barriers that challenge conventional therapeutic approaches. This review navigates the intricate landscape of TB treatment, from the stealth of latent infections and the strength of granuloma formations to the daunting specters of drug resistance and altered gene expression. Amidst these challenges, traditional therapies often fail, contending with inconsistent bioavailability, prolonged treatment regimens, and socioeconomic burdens. Nanoscale Drug Delivery Systems (NDDSs) emerge as a promising beacon, ready to overcome these barriers, offering better drug targeting and improved patient adherence. Through a critical approach, we evaluate a spectrum of nanosystems and their efficacy against MTB both in vitro and in vivo. This review advocates for the intensification of research in NDDSs, heralding their potential to reshape the contours of global TB treatment strategies. (AU)

• Processo FAPESP: 20/16573-3 - Estudos in vitro e in vivo de análogos do peptídeo antimicrobiano B1CTcu5 encapsulados em micropartículas colón-específicas frente ao Mycobacterium tuberculosis
• Beneficiário: Cesar Augusto Roque Borda
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 22/02661-3 - Avaliação do potencial de nanopartículas de silício poroso funcionalizadas com cetuximabe para veiculação de docetaxel no tratamento do câncer de próstata
• Beneficiário: Rafael Miguel Sábio
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático