Efficacy of a Standalone Smartphone Application to Treat Postnatal Depression: A Randomized Controlled Trial

Autor(es)

Zuccolo, Pedro F. ; Brunoni, Andre R. ; Borja, Tatiane ; Matijasevich, Alicia ; Polanczyk, Guilherme V. ; Fatori, Daniel

• Tipo de documento: Artigo Científico
• Fonte: PSYCHOTHERAPY AND PSYCHOSOMATICS; v. 93, n. 6, p. 13-pg., 2024-10-23.

Resumo

Introduction: Smartphone app interventions based on cognitive-behavioral therapy are promising scalable alternatives for treating mental disorders, but the evidence of their efficacy for postpartum depression is limited. Objective: To evaluate the efficacy of Motherly, a standalone CBT-based smartphone app, in reducing symptoms of postpartum depression. Methods: women aged 18-40 with symptoms of postpartum depression were randomized either to intervention (Motherly app) or active control (COMVC app). The primary outcome was symptoms of depression measured by the Edinburgh Postnatal Depression Scale (EPDS) at post-treatment. Secondary outcomes were anxiety symptoms, parental stress, quality of sleep, behavioral activation, availability of response-contingent positive reinforcement, and clinical improvement at post-treatment and 1-month follow-up. Exploratory analyses were performed to explore if app engagement was associated with treatment response. Results: From November 2021 to August 2022, 1751 women volunteered, of which 264 were randomized, and 215 provided primary outcome data. No statistically significant differences were found between groups at post-treatment: intervention: Mean (SD): 12.75 (5.52); active control: 13.28 (5.32); p=0.604. There was a statistically significant effect of the intervention on some of the secondary outcomes. Exploratory analyses suggest a dose-response relationship between Motherly app engagement and outcomes. Conclusions: our standalone app intervention did not significantly reduce postnatal depression symptoms when compared to active control. Exploratory findings suggest that negative findings might be associated with insufficient app engagement. Consistent with current literature, our findings suggest that standalone app interventions for postpartum depression are not ready to be implemented in clinical practice. (AU)

• Processo FAPESP: 16/13451-9 - Desenvolvendo medidas ecológicas e frequentes da estimulação cognitiva e psicossocial na infância no contexto de um programa de visitação para jovens gestantes
• Beneficiário: Daniel Graça Fatori de Sá
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/12439-3 - Explorando fenótipos digitais de depressão e ansiedade com sensores de smartphones em ensaios clínicos randomizados
• Beneficiário: Pedro Fonseca Zuccolo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/12901-9 - Centro Nacional de Ciência e Inovação em Saúde Mental (CISM)
• Beneficiário: Eurípedes Constantino Miguel Filho
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa Aplicada