Mitochondrial redox state, bioenergetics, and calcium transport in caloric restriction: A metabolic nexus

Autor(es)

Vilas-Boas, Eloisa A. ; Kowaltowski, Alicia J.

• Tipo de documento: Artigo Científico
• Fonte: Free Radical Biology and Medicine; v. 219, p. 20-pg., 2024-04-29.

Resumo

Mitochondria congregate central reactions in energy metabolism, many of which involve electron transfer. As such, they are expected to both respond to changes in nutrient supply and demand and also provide signals that integrate energy metabolism intracellularly. In this review, we discuss how mitochondrial bioenergetics and reactive oxygen species production is impacted by dietary interventions that change nutrient availability and impact on aging, such as calorie restriction. We also discuss how dietary interventions alter mitochondrial Ca2+ 2 + transport, regulating both mitochondrial and cytosolic processes modulated by this ion. Overall, a plethora of literature data support the idea that mitochondrial oxidants and calcium transport act as integrating signals coordinating the response to changes in nutritional supply and demand in cells, tissues, and animals. (AU)

• Processo FAPESP: 20/06970-5 - Transportadores iônicos mitocondriais como sensores e reguladores do metabolismo energético
• Beneficiário: Alicia Juliana Kowaltowski
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 21/02481-2 - Regulação do metabolismo energético por transporte de cálcio no fígado
• Beneficiário: Eloisa Aparecida Vilas Boas
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado