Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats

Autor(es)

Ayala, Carolina ^[1] ; Ruth Valdez, Susana ^{[2, 3]} ; Lujan Navarra Morero, Maria ^[1] ; Soaje, Marta ^{[2, 4]} ; Beatriz Carreno, Norma ^[2] ; Silvina Sanchez, Monica ^[5] ; Bittencourt, Jakson Cioni ^{[6, 7]} ; Alma Jahn, Graciela ^[2] ; Ester Celis, Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Nacl Cordoba, Fac Ciencias Med, Catedra Bacteriol & Virol Med, Lab Ciencias Fisiol, RA-5000 Cordoba - Argentina

^[2] CCT CONICET Mendoza, Consejo Nacl Invest Cient & Tecn IMBECU CONICET, Inst Biol Med Expt Cuyo, Lab Reprod & Lactancia, RA-5500 Mendoza - Argentina

^[3] Univ Nacl Cuyo, Inst Ciencias Basicas ICB, RA-5500 Mendoza - Argentina

^[4] Univ Nacl Cuyo, Fac Ciencias Med, Dept Morfofisiol, RA-5500 Mendoza - Argentina

^[5] Minist Ciencia & Tecn MINCyT, Ctr Excelencia Prod & Proc Cordoba CEPROCOR, Cordoba - Argentina

^[6] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Lab Chem Neuroanat, BR-04023900 Sao Paulo - Brazil

^[7] Univ Sao Paulo, Inst Psychol, Ctr Neurosci & Behav, BR-04023900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Peptides; v. 32, n. 6, p. 1249-1254, JUN 2011.
• Citações Web of Science: 6

Resumo

To date, there has been only one in vitro study of the relationship between neuropeptide EI (NEI) and the hypothalamic-pituitary-thyroid (HPT) axis. To investigate the possible relationship between NEI and the HPT axis, we developed a rat model of hypothyroidism and hyperthyroidism that allows us to determine whether NEI content is altered in selected brain areas after treatment, as well as whether such alterations are related to the time of day. Hypothyroidism and hyperthyroidism, induced in male rats, with 6-propyl-1-thiouracil and L-thyroxine, respectively, were confirmed by determination of triiodothyronine, total thyroxine, and thyrotropin levels. All groups were studied at the morning and the afternoon. In rats with hypothyroidism, NEI concentration, evaluated on postinduction days 7 and 24, was unchanged or slightly elevated on day 7 but was decreased on day 24. In rats with hyperthyroidism, NEI content, which was evaluated after 4 days of L-thyroxine administration, was slightly elevated, principally in the preoptic area in the morning and in the median eminence-arcuate nucleus and pineal gland in the afternoon, the morning and afternoon NEI contents being similar in the controls. These results provide the bases to pursue the study of the interaction between NEI and the HPT axis. (C) 2011 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 04/13849-5 - Circuitos peptidérgicos envolvidos na organização do comportamento alimentar
• Beneficiário: Jackson Cioni Bittencourt
• Linha de fomento: Auxílio à Pesquisa - Temático