| Texto completo | |
| Autor(es): Mostrar menos - |
de Souza, Rodrigo Medeiros
;
dos Santos, Maria Ines
;
Gomes, Laura Cordeiro
;
de Melo, Bruna Beatriz Pedroza
;
Separovic, Erika Paula Machado
;
Murillo, Oscar
;
Wunderlich, Gerhard
;
Clark, Taane Gregory
;
Campino, Susana
;
Epiphanio, Sabrina
;
Marinho, Claudio Romero Farias
;
Dombrowski, Jamille Gregorio
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS Neglected Tropical Diseases; v. 18, n. 11, p. 15-pg., 2024-11-01. |
| Resumo | |
Background Plasmodium vivax infection, when it occurs during pregnancy, has often been associated with serious adverse pregnancy outcomes. However, immunological alterations in pregnancy and their consequences have been little explored. We characterized the humoral immune response in pregnant women exposed to malaria by P. vivax antigens and its association with the maternal inflammatory profile and poor pregnancy outcomes.Methods An observational cohort study in the Brazilian Amazon was conducted between 2013 and 2015. After applying exclusion criteria, 242 mother-child pairs were included in the analysis. Data on maternal infection, gestational outcomes, and inflammatory factors were evaluated in the maternal peripheral plasma. In samples from the first infection, the presence of total IgG and its subclasses in plasma against PvMSP119 protein were also quantified.Results Previous exposure to malaria, observed by anti-total IgG antibodies to the PvMSP119 antigen, increased the inflammatory response to infection when the pregnant woman had malaria during pregnancy. IL-6 and IL-10 levels were positively correlated with parasitemia and with total IgG levels; but they were negatively correlated with the gestational age at delivery from Pv-infected woman. In multivariate linear regression analyses, IgG 1, 2 and 4 was negatively and positively associated with cytokines IL-6 and IL-10, respectively, in P. vivax-infection.Conclusions An association between the humoral immune response and the peripheral inflammatory cytokine profile with the adverse outcomes in malaria in pregnancy by P. vivax was observed. Previous exposure to the parasite can influence the IL-6 and IL-10 response, which is associated with increased parasitemia, reduced maternal weight gain and premature delivery. (AU) | |
| Processo FAPESP: | 20/03163-1 - Perfil proteômico pulmonar da Síndrome do Desconforto Respiratório Agudo associada à Malária: identificação e validação de biomarcadores |
| Beneficiário: | Sabrina Epiphanio |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/06747-4 - Estudo da resposta imune humoral nas infecções recorrentes por Plasmodium vivax em gestantes da região amazônica |
| Beneficiário: | Cláudio Romero Farias Marinho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/13950-3 - Inflamação induzida por Malária: uma nova via para doenças cardiovasculares |
| Beneficiário: | Laura Cordeiro Gomes |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 21/07170-5 - Identificação de biomarcadores para restrição do crescimento fetal durante a Malária gestacional |
| Beneficiário: | Maria Ines dos Santos |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 19/12068-5 - Identificação de biomarcadores preditivos de disfunção placentária na Malária |
| Beneficiário: | Jamille Gregório Dombrowski |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 22/13150-0 - Inflamação induzida por Malária: uma nova via para doenças cardiovasculares |
| Beneficiário: | Cláudio Romero Farias Marinho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |