Chitosan surface modification modulates the mucoadhesive, permeation and anti-angiogenic properties of gellan gum/bevacizumab nanoparticles

Autor(es)

Carvalho, Suzana Goncalves ; Haddad, Felipe Falcao ; dos Santos, Aline Martins ; Scarim, Caue Benito ; Ferreira, Leonardo Miziara Barboza ; Meneguin, Andreia Bagliotti ; Chorilli, Marlus ; Gremiao, Maria Palmira Daflon

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Biological Macromolecules; v. 263, p. 9-pg., 2024-02-19.

Resumo

Bevacizumab (BVZ) was the first monoclonal antibody approved by the FDA and has shown an essential advance in the antitumor therapy of colorectal cancer (CRC), however, the systemic action of BVZ administered intravenously can trigger several adverse effects. The working hypothesis of the study was to promote the modulation of the mucoadhesion properties and permeability of the BVZ through the formation of nanoparticles (NPs) with gellan gum (GG) with subsequent surface modification with chitosan (CS). NPs comprising BVZ and GG were synthesized through polyelectrolyte complexation, yielding spherical nanosized particles with an average diameter of 264.0 +/- 2.75 nm and 314.0 +/- 0.01 nm, polydispersity index of 0.182 +/- 0.01 e 0.288 +/- 0.01, and encapsulation efficiency of 29.36 +/- 0.67 e 60.35 +/- 0.27 mV, for NPs without (NP_BVZ) and with surface modification (NP_BVZ + CS). The results showed a good ability of nanoparticles with surface modification to modulate the NPs biological properties. (AU)

• Processo FAPESP: 22/14075-1 - Sistemas multifuncionais baseados em polissacarídeos para liberação colón específica de pós-bióticos e seu potencial para aplicação no tratamento e prevenção de doenças inflamatórias intestinais
• Beneficiário: Suzana Gonçalves Carvalho
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/10761-5 - Sistemas multifuncionais destinados à liberação cólon específica do bevacizumabe para o tratamento do Câncer Colorretal
• Beneficiário: Suzana Gonçalves Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático