Evaluation of ent-Kaurenoic Acid Derivatives for their Anticariogenic Activity

Autor(es):Mostrar menos -

de Andrade, Bruna B. ^[1] ; Moreira, Monique R. ^[1] ; Ambrosio, Sergio R. ^[1] ; Furtado, Niege A. J. C. ^[2] ; Cunha, Wilson R. ^[1] ; Heleno, Vladimir C. G. ^[1] ; Silva, Aline N. ^[1] ; Simao, Marilia R. ^[1] ; da Rocha, Erilda M. P. ^[1] ; Martins, Carlos H. G. ^[1] ; Veneziani, Rodrigo C. S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14049 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT COMMUNICATIONS; v. 6, n. 6, p. 777-780, JUN 2011.
• Citações Web of Science: 22

Resumo

Ent-kaur-16(17)-en-19-oic acid (kaurenoic acid, KA) is a tetracyclic diterpene prototype for natural anticaries agents. Six KA derivatives were prepared and their antimicrobial activity against the main microorganisms involved in the caries process evaluated. The sodium salt of KA (KA-Na) was the most active, displaying very promising MIC values for most pathogens. Time-kill assays against the primary causative agent of caries (Streptococcus mutans) indicated that KA and KA-Na only inhibited growth in the first 12 h, suggesting a bacteriostatic effect. After this period (12-24 h), their bactericidal effect was clearly noted. KA and KA-Na showed no synergy when combined with the gold standard anticariogenic (chlorhexidine dihydrochloride, CHD) in the checkerboard assays against S. mutans. (AU)

• Processo FAPESP: 09/05550-3 - Determinação da Concentração Inibitória Mínima, Concentração Bactericida Mínima e Tempo de Morte para diterpenos do tipo caurano frente a bactérias cariogênicas.
• Beneficiário: Bruna Beraldo de Andrade
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica