| Full text | |
| Author(s): Show less - |
de Andrade, Bruna B.
[1]
;
Moreira, Monique R.
[1]
;
Ambrosio, Sergio R.
[1]
;
Furtado, Niege A. J. C.
[2]
;
Cunha, Wilson R.
[1]
;
Heleno, Vladimir C. G.
[1]
;
Silva, Aline N.
[1]
;
Simao, Marilia R.
[1]
;
da Rocha, Erilda M. P.
[1]
;
Martins, Carlos H. G.
[1]
;
Veneziani, Rodrigo C. S.
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | NATURAL PRODUCT COMMUNICATIONS; v. 6, n. 6, p. 777-780, JUN 2011. |
| Web of Science Citations: | 22 |
| Abstract | |
Ent-kaur-16(17)-en-19-oic acid (kaurenoic acid, KA) is a tetracyclic diterpene prototype for natural anticaries agents. Six KA derivatives were prepared and their antimicrobial activity against the main microorganisms involved in the caries process evaluated. The sodium salt of KA (KA-Na) was the most active, displaying very promising MIC values for most pathogens. Time-kill assays against the primary causative agent of caries (Streptococcus mutans) indicated that KA and KA-Na only inhibited growth in the first 12 h, suggesting a bacteriostatic effect. After this period (12-24 h), their bactericidal effect was clearly noted. KA and KA-Na showed no synergy when combined with the gold standard anticariogenic (chlorhexidine dihydrochloride, CHD) in the checkerboard assays against S. mutans. (AU) | |
| FAPESP's process: | 09/05550-3 - Determination of Minimum Inhibitory Concentration, Minimum Bactericidal Concentration and Time-kill Curve for Kaurane-type diterpenes against oral pathogens. |
| Grantee: | Bruna Beraldo de Andrade |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |