| Texto completo | |
| Autor(es): |
de Morais, Paula Bertin
;
de Almeida, Gerson Santos
;
Andrade, Amanda Fantini de Camargo
;
Orsi, Ricardo de Oliveira
;
Zambuzzi, Willian Fernando
;
Fernandes, Celio Jr. Da Costa
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | TISSUE & CELL; v. 94, p. 10-pg., 2025-02-22. |
| Resumo | |
Numerous studies have demonstrated the significant role of propolis in various biological processes, including inflammation and the repair of endothelial and bone tissues. The cascade of inflammation, proliferation, and tissue remodeling characterizes the injury site. Remarkable progress has been made in the field of alternative medicine with the utilization of propolis. In this study, we specifically investigated the effects of alcoholic extract of propolis on cell adhesion, survival, remodeling, and differentiation pathways in osteoblasts. Our findings revealed the activation of survival proteins such as AKT, ERK, and phosphorylated ERK during the adhesion phase, while interleukins, specifically IL-6 and TNF, exhibited increased expression during cell differentiation. Furthermore, treatment with propolis extract led to enhanced activity of metalloproteinases (MMP9 and MMP2) and HIF-1 alpha, a crucial activator of angiogenesis and bone remodeling. It was observed that the alcoholic propolis extract stimulated cell proliferation, differentiation, and repair, with key molecules involved in these processes including pro-inflammatory factors IL-6 and TNF alpha, as well as HIF-1, MMP2, and BMP7 proteins. Collectively, these factors induced an initial state of proliferation followed by differentiation and repair. Therefore, the alcoholic extract of propolis holds promise as a potential therapeutic agent, particularly in cases involving tissue repair. Nevertheless, further comprehensive in vitro and in vivo studies targeting this area are necessary to advance our understanding. (AU) | |
| Processo FAPESP: | 19/04495-0 - O papel do hormônio da tireóide 3,3',5 - triiodotironina (T3) na expressão de lipocalina 2 (LCN2) e sua contribuição em mecanismos fisiológicos de ingesta alimentar |
| Beneficiário: | Amanda Fantini de Camargo Andrade |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 14/22689-3 - Sinalização parácrina mediada por microvesículas e proteínas entre células ósseas e endoteliais durante o desenvolvimento e regeneração do tecido ósseo |
| Beneficiário: | Willian Fernando Zambuzzi |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 16/08888-9 - Sinalização parácrina mediada por microvesículas e proteínas entre células ósseas e endoteliais durante o desenvolvimento e regeneração do tecido ósseo |
| Beneficiário: | Célio Junior da Costa Fernandes |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 19/21807-6 - Sinalização parácrina mediada por microvesículas e proteínas entre células ósseas e endoteliais durante o desenvolvimento e regeneração do tecido ósseo |
| Beneficiário: | Célio Junior da Costa Fernandes |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |