| Texto completo | |
| Autor(es): |
Oliveira, Samuel dos Santos
;
da Silva, Joao Vinicius Honorio
;
Vieira, Raquel de Souza
;
Moreira, Luis Felipe Serra
;
Bandeira, Pedro Henrique Araujo
;
Ramos, Beatriz Leocata
;
Silva, Marco Antonio Ataide
;
Camara, Niels Olsen Saraiva
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN IMMUNOLOGY; v. 16, p. 11-pg., 2025-05-13. |
| Resumo | |
The downstream signaling pathways of TLR activation involve a family of adaptor proteins, including MYD88, TIRAP, TRIF, TRAM, and SARM1. The first four proteins stimulate inflammatory and antiviral responses, playing crucial roles in innate immunity against various pathogens. In contrast, SARM1 promotes immunity to microorganisms in invertebrate animals independently of TLRs, and negatively regulates inflammatory responses in metazoan organisms. SARM1 inhibits TRIF, reduces the activation of various inflammasomes, and induces mitochondrial damage and cell death to eliminate hyperactivated cells. This regulation is essential to ensure timely control of immune responses and to prevent excessive inflammation. Recently, it was discovered that SARM1 can hydrolyze NAD, a critical component of cellular metabolism. The reduction of NAD levels by SARM1 is linked to the progression of Wallerian degeneration following neuronal injury and may also play a role in the immunoregulation of lymphoid and myeloid cells. Since SARM1 can be pharmacologically modulated, it presents promising opportunities for developing treatments for inflammatory and neurodegenerative diseases. (AU) | |
| Processo FAPESP: | 23/07482-2 - Detecção de estressores extra e intracelulares por células renais e imunes: novos insights sobre recepção e transdução de sinais e sua relevância para a compreensão de doenças renais |
| Beneficiário: | Niels Olsen Saraiva Câmara |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 22/16176-0 - O papel do SARMI na ativação e diferenciação de células T CD4 |
| Beneficiário: | Samuel dos Santos Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |