| Texto completo | |
| Autor(es): |
Sipoloni, Victor Menezes
;
Silva-Silva, Joao Victor
;
Ferreira, Elthon G.
;
Lee, Eric Yoshitaka
;
Batista Junior, Joao Marcos
;
Uemi, Miriam
;
de Medeiros, Livia Soman
;
Jimenez, Paula C.
;
Veiga, Thiago A. M.
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRY & BIODIVERSITY; v. N/A, p. 15-pg., 2025-05-26. |
| Resumo | |
The chemical study of the ethanolic extract from the roots of Vicia faba led to the isolation of two isoflavonoids, alfalone and 8-O-methylretusine, as well as a mixture of rotenoids, including clitoriacetal and clitoriacetal B, the latter of which is reported for the first time. These compounds were characterized through nuclear magnetic resonance and vibrational circular dichroism spectroscopies, and density functional theory calculations. The rotenoid mixture exhibited cytotoxic activity against HCT-116, MCF-7, and 501Mel cell lines, while showing no significant toxicity to NIH/3T3 cells. The predictive analysis identified several shared therapeutic targets across colorectal cancer, breast cancer, and melanoma. Key sites, including hypoxia-inducible factor 1-alpha (HIF1A), estrogen receptor, heat shock protein HSP 90-beta, and heat shock protein HSP 90-alpha, were highlighted for their critical roles in tumor progression and therapeutic resistance. Notably, clitoriacetal demonstrated an affinity for HIF1A, suggesting its involvement in the observed antitumor effects, likely through modulation of the HIF1A pathway. These findings underscore the potential of V. faba root-derived compounds as promising candidates for targeted cancer therapies. (AU) | |
| Processo FAPESP: | 24/17686-7 - Estereoquímica de lignanas furofurânicas por dispersão rotatória óptica: interação entre teoria e experimento |
| Beneficiário: | Eric Yoshitaka Lee |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 23/00242-6 - Avaliação de Propriedades Biológicas e Farmacocinéticas de Candidatas a Fármacos |
| Beneficiário: | João Victor da Silva e Silva |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 23/12475-5 - Sistematizando propriedades quirópticas de lignanas: implicações para o assinalamento correto de configuração absoluta |
| Beneficiário: | João Marcos Batista Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 22/12654-4 - Mixobactérias marinhas do estado de São Paulo como fonte de inibidores de proteases |
| Beneficiário: | Paula Christine Jimenez |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Regular |
| Processo FAPESP: | 18/04095-0 - Abordagens analíticas para a descoberta de compostos citotóxicos desconhecidos a partir de plantas |
| Beneficiário: | Thiago André Moura Veiga |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |