| Texto completo | |
| Autor(es): Mostrar menos - |
Borsoi, Felipe Tecchio
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Arruda, Henrique Silvano
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Andrade, Amanda Cristina
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dos Santos, Monica Pezenatto
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da Silva, Isabelle Nogueira
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Marson, Leonardo Augusto
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Saliba, Ana Sofia Martelli Chaib
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de Alencar, Severino Matias
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Geraldo, Murilo Vieira
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Neri Numa, Iramaia Angelica
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Pastore, Glaucia Maria
Número total de Autores: 11
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| Tipo de documento: | Artigo Científico |
| Fonte: | PLANTS-BASEL; v. 14, n. 11, p. 23-pg., 2025-05-30. |
| Resumo | |
In the present study, we characterized and investigated the effect of the ara & ccedil;& aacute;-boi extract on antioxidant activity, cell viability, and the regulation of genes related to tumor suppression and epigenetic mechanisms in ovarian cancer cells. The results showed that ara & ccedil;& aacute;-boi extract revealed a remarkable diversity of phytochemicals (organic acids, phenolic acids, and flavonoids), significant antioxidant potential, and efficient scavenging of reactive oxygen species, particularly hydroxyl and peroxyl radicals. Gallic acid, one of the phenolic acids present in the extract, was used alone to verify its contribution to cytotoxic activities. Exposure of human ovarian cancer cells (NCI/ADR-RES and OVCAR3) to the extract (0.15-150 mu g/mL) and gallic acid (6-48 mu g/mL) resulted in a significant reduction in cell viability, particularly after 48 h of treatment. Both treatments modulated genes involved in DNA repair, tumor suppression, and epigenetic regulation. However, no changes were observed in the methylation status of the BRCA1 gene promoter region with either ara & ccedil;& aacute;-boi extract or gallic acid. These findings reinforce the therapeutic potential of ara & ccedil;& aacute;-boi extract and its phenolic compounds against ovarian cancer and point to the need for further studies to better elucidate the molecular pathways involved and validate these effects in vivo. (AU) | |
| Processo FAPESP: | 20/08761-4 - Caracterização química de compostos bioativos de plantas alimentícias não convencionais (panc) para o desenvolvimento de produtos com apelo funcional |
| Beneficiário: | Glaucia Maria Pastore |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |