| Texto completo | |
| Autor(es): |
Romano, Minna Moreira Dias
;
Moreira, Henrique Turin
;
Alenezi, Fawaz
;
Kisslo, Joseph
;
Lombo Lievano, Bernardo
;
Schmidt, Andre
;
Maciel, Benedito Carlos
;
Marin-Neto, Jose Antonio
;
Velazquez, Eric J.
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS Neglected Tropical Diseases; v. 19, n. 8, p. 11-pg., 2025-08-01. |
| Resumo | |
Introduction: Chronic Chagas cardiomyopathy (CCC) is associated with a high incidence of cardiovascular events. Global longitudinal strain (GLS) is useful in predicting adverse cardiovascular outcomes in several cardiomyopathies. However, its prognostic value in CCC is not well established. Methods: This study was a retrospective echocardiography analysis with prospective follow-up of CCC subjects. GLS was defined as the average of three apical peak longitudinal strain measurements of the LV using vendor-independent software. GLS groups were defined according to tertiles: (1) GLS <= -18.4%, (2) GLS > -18.4% and <-13.8%, and (3) GLS >= -13.8%. The primary outcome was a composite of death, hospitalization, sustained ventricular tachycardia (SVT), new heart failure, any systemic embolism, hospitalization, reverted cardiac arrest and cardiac heart transplantation. Results: GLS was obtained in 77 subjects, 50.6% were males and the mean age was 56 +/- 15 years. There were 6.49% losses of follow-up and the mean LVEF was 51 +/- 14%. After a follow-up period of 35 +/- 19 months (2.9 y), 33 subjects reached the composite outcome. Death and hospitalization were the most frequent outcomes (n = 9), followed by new heart failure (n = 6), embolism (n = 6), and SVT (n = 3). The GLS >= -13.8% was associated with a worse prognosis when compared with the other tertile GLS groups (log rank-p-value = 0.001 for both comparisons). On the multivariate Cox proportional hazard model, adjusting for age, gender, and LVEF, GLS was an independent predictor of outcomes with an HR of 1.20 (CI = 1.05-1.38;p = 0.008). Conclusion: Left ventricle GLS is an independent predictor of cardiovascular outcomes in patients with CCC. GLS may be an important tool for Chagas disease risk stratification, independent of LVEF. (AU) | |
| Processo FAPESP: | 15/24319-1 - Avaliação da função sistólica biventricular na doença de Chagas, com o uso de técnicas ecocardiográficas de análise de deformidade miocárdica, e sua correlação com ressonância magnética cardíaca. |
| Beneficiário: | Minna Moreira Dias Romano |
| Modalidade de apoio: | Bolsas no Exterior - Pesquisa |
| Processo FAPESP: | 16/25403-9 - Investigações sobre etiopatogenia, fisiopatologia e terapêutica em humanos e em modelo experimental com a cardiomiopatia da Doença de Chagas |
| Beneficiário: | José Antonio Marin-Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |