New Roles for Innate Immune Response in Acute and Chronic Kidney Injuries

Autor(es)

Goncalves, G. M. ; Castoldi, A. ^[1] ; Braga, T. T. ; Camara, N. O. S. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Div Nephrol, Lab Clin & Expt Immunol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Lab Transplantat Immunobiol, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Scandinavian Journal of Immunology; v. 73, n. 5, p. 428-435, MAY 2011.
• Citações Web of Science: 28

Resumo

The innate immune system plays an important role as a first response to tissue injury. This first response is carried out via germline-encoded receptors. They can recognize exogenous Pathogen-Associated Molecular Patterns and endogenous Dangers-Associated Molecular Patterns. The Toll-Like Receptor (TLR) family is well-studied, but more recently another family in the cytoplasmic compartment, called nod-like receptor (NLR), was discovered. In addition to being present in inflammatory cells, these receptors are widely distributed in various cell types, including renal tissue, where these receptors have an important role in triggering the inflammatory response during renal diseases. This review summarizes the present data regarding the role of TLRs and NLRs in the course and development of various kidney pathologies. (AU)

• Processo FAPESP: 07/07139-3 - Investigando o papel da heme-oxigenase 1 em diferentes processos inflamatórios renais em modelos animais
• Beneficiário: Niels Olsen Saraiva Câmara
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 08/55447-1 - Papel dos NOD-like receptor (NLR) na fisiopatogenia de insuficiência renal aguda (IRA) isquêmica e séptica
• Beneficiário: Giselle Martins Gonçalves
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado