| Texto completo | |
| Autor(es): |
Splendore, Carolina Oliveira
;
de Oliveira, Mariana G.
;
Costa, Fernando Ferreira
;
Silva, Fabio Henrique
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ANTIOXIDANTS; v. 14, n. 10, p. 14-pg., 2025-10-08. |
| Resumo | |
Priapism is a frequent and debilitating complication in patients with sickle cell disease (SCD), characterized by recurrent ischemic episodes that can culminate in fibrosis of the erectile tissue and irreversible erectile dysfunction. Despite significant advancements in the management of acute episodes, current therapies remain largely ineffective in preventing recurrences, emphasizing the need for novel strategies that target the underlying pathophysiology. This narrative review describes the mechanistic links between oxidative stress and nitric oxide (NO) dysregulation in the pathogenesis of SCD-associated priapism, with a particular focus on the NO-cyclic guanosine monophosphate (cGMP)-phosphodiesterase type 5 (PDE5) signaling axis. We analyze preclinical evidence supporting resveratrol, a natural polyphenolic compound, as well as its NO-donor hybrid derivatives, as emerging therapeutic candidates. Additionally, we discuss the potential of combining resveratrol with current treatment approaches, and address the translational challenges that must be overcome to move from preclinical data to clinical application. Taken together, the evidence presented in this review supports resveratrol-based therapies as a promising approach for oxidative-stress-driven priapism in SCD and delineates critical perspectives for their further investigation. (AU) | |
| Processo FAPESP: | 17/08122-9 - Priapismo e disfunção miccional na Anemia Falciforme: fisiopatologia e novos candidatos a fármacos |
| Beneficiário: | Fábio Henrique da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 19/18886-1 - Mecanismos fisiopatológicos e tratamento das anormalidades das células vermelhas do sangue |
| Beneficiário: | Fernando Ferreira Costa |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |