| Texto completo | |
| Autor(es): |
Parra, Aline N. S.
;
Rocha, Ana Carolina F. S.
;
Pavan, Julian C. S.
;
Machado, Analuz da Silva
;
Rodrigues, Vinicius Jose Miranda
;
dos Santos, Daiane Albino
;
Magalhaes, Lizandra G.
;
de Albuquerque, Sergio
;
Heleno, Vladimir C. G.
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY; v. 17, n. 4, p. 7-pg., 2025-04-01. |
| Resumo | |
This paper describes the obtention of fourteen derivatives from four natural labdane diterpenes isolated from Copaifera oleoresin, named ent-copalic acid (1), ent-3(3-acetoxy copalic acid (2), ent-3(3-hydroxy copalic acid (3) and ent-agathic acid (4). All eighteen compounds, derivatives and precursors, were assayed against the promastigote form of Leishmania amazonensis and trypomastigote forms of Trypanosoma cruzi, revealing two promising compounds with leishmanicidal activity (IC50 = 5.94 mu M and 5.31 mu M) and three promising compounds with trypanocidal activity, two of them (IC50 = 13.31 mu M and IC50 = 15.05 mu M) displaying similar activity as the reference drug (IC50 = 13.12 mu M) and one of them being even more potent with an IC50 = 0.425 mu M. (AU) | |
| Processo FAPESP: | 09/09491-1 - Modificação estrutural e estudos detalhados por RMN de produtos naturais de interesse biológico |
| Beneficiário: | Vladimir Constantino Gomes Heleno |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |