| Texto completo | |
| Autor(es): |
de Souza Ferreira, Luiz Philipe
;
dos Santos, Diego Dias
;
Lourenco, Renata Pereira
;
Sanches, Jose Marcos
;
Gil, Cristiane D.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEUROGLIA; v. 6, n. 3, p. 11-pg., 2025-08-28. |
| Resumo | |
Pain is a multifactorial phenomenon involving neuronal, immune, and glial components. Annexin A1 (AnxA1), a glucocorticoid-regulated protein with pro-resolving properties, has emerged as a critical modulator of pain. Present in both peripheral and central compartments, AnxA1 acts through the formyl peptide receptor FPR2/ALX to regulate immune responses, modulate nociceptive signaling, and promote tissue homeostasis. Its mimetic peptide, Ac2-26, has demonstrated robust antinociceptive effects in various pain models, including those induced by inflammation, tissue injury, viral infection, and opioid exposure. AnxA1 modulates cytokine expression, inhibits pro-nociceptive pathways such as TRPV1 and CXCL12/CXCR4, and reprograms macrophages. In the central nervous system, it attenuates neuroinflammation and central sensitization. Notably, AnxA1 can exhibit context-dependent effects, contributing to either the resolution or exacerbation of inflammation. This review examines the molecular mechanisms by which AnxA1 bridges the immune and nervous system pathways, highlighting its therapeutic potential in pain management. (AU) | |
| Processo FAPESP: | 22/02327-6 - Impacto do tratamento farmacológico com o peptídeo mimético da Anexina A1 em modelo experimental da Doença de Parkinson |
| Beneficiário: | Cristiane Damas Gil |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 23/16282-7 - Papel da anexina a1 na biologia dos hepatócitos: estudo em modelos experimentais de diabetes in vivo e in vitro |
| Beneficiário: | Diego Dias dos Santos |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 21/00270-4 - Papel da proteína Anexina A1 em modelo experimental da Doença de Parkinson |
| Beneficiário: | Luiz Philipe de Souza Ferreira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |