| Texto completo | |
| Autor(es): Mostrar menos - |
Duarte Batista, Lais
;
Tucker, Katherine L.
;
Bigornia, Sherman
;
Noel, Sabrina E.
;
Harris, William S.
;
Marques Braga, Ribanna A.
;
Valentini Neto, Joao
;
Teixeira Damasceno, Nagila R.
;
Macedo Rogero, Marcelo
;
Mori Sarti, Flavia
;
Mattei, Josiemer
;
Fisberg, Regina M.
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BRITISH JOURNAL OF NUTRITION; v. N/A, p. 12-pg., 2025-08-22. |
| Resumo | |
The n-3 index has been proposed as a risk factor for CVD endpoints. However, the association of the O3I defined with different cut-offs and cardiometabolic risk factors has been less studied. This study aimed to investigate the association between two cut-off points of the O3I and cardiometabolic risk factors in Brazilian and Puerto Rican adults. This cross-sectional analysis included 249 Brazilians and 1261 Puerto Ricans, aged 45-75 years. Fatty acids composition was quantified in erythrocyte membranes using GC with a flame ionisation detector. The O3I was categorised as <= 4 % (low), > 4-8 % (intermediate) and >= 8 % (desirable), and as <= 4 % (very low), > 4-6 % (low), > 6-8 % (moderate) and > 8 % (high) in the second cut-off classification. Serum lipids, waist circumference and insulin resistance were measured from standardised protocols. Multivariable-adjusted linear models tested the association between the O3I and cardiometabolic factors. Brazilians had a mean (sd) O3I of 4<middle dot>65 % (1<middle dot>19 %) v. 4<middle dot>43 % (1<middle dot>14 %) in Puerto Ricans (P = 0<middle dot>033), with only 1<middle dot>6 % of Brazilians and 1<middle dot>2 % of Puerto Ricans presenting a desirable/high O3I. The O3I, as continuous or for > 4 % (v. <= 4 %), was inversely associated with TAG, VLDL and TAG/HDL-cholesterol ratio in Puerto Ricans. In Brazilians, an O3I > 6 % (v. <= 6 %) was associated with higher total cholesterol, LDL-cholesterol and non-HDL-cholesterol. Both populations presented O3I below the desirable levels, and the magnitude and direction of associations with cardiometabolic factors varied by study and cut-offs, reinforcing the importance of expanding these investigations to more diverse populations. (AU) | |
| Processo FAPESP: | 17/05125-7 - Estilo de vida, marcadores bioquímicos e genéticos como fatores de risco cardiometabólico: inquérito de saúde na cidade de São Paulo |
| Beneficiário: | Regina Mara Fisberg |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 22/11755-1 - Identificação e comparação de pontos de corte para o índice ômega-3 relacionado com fatores de risco cardiometabólico em adultos brasileiros e porto-riquenhos |
| Beneficiário: | Lais Duarte Batista |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |