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| Autor(es): Mostrar menos - |
de Campos, Gabriel Montenegro
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Costa, Thalita Cristina de Mello
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da Silva, Anielly Sarana
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Costa, Lara Okuyama Afonso
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Silveira, Roberta Maraninchi
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Valenca, Ian Nunes
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de Carvalho, Felipe Santos
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Darrigo Jr, Luiz Guilherme
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Haddad, Rodrigo
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Vieira, Ana Carolina de Jesus
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Mesquita, Camila Campos
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Laurindo, Patricia da Silva
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Cunha, Renato Guerino
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Alcantara, Luiz Carlos Junior
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Kashima, Simone
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Covas, Dimas Tadeu
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Simoes, Belinda Pinto
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Sampaio, Sandra Coccuzzo
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Elias, Maria Carolina
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Giovanetti, Marta
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Junqueira, Dennis Maletich
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Slavov, Svetoslav Nanev
Número total de Autores: 22
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| Tipo de documento: | Artigo Científico |
| Fonte: | TRANSPLANT INFECTIOUS DISEASE; v. 27, n. 4, p. 9-pg., 2025-04-29. |
| Resumo | |
BackgroundCommensal viruses are typically well-tolerated by healthy individuals, but their behavior in immunocompromised patients is not fully understood.MethodsThis study investigated the prevalence, molecular dynamics, and circulating genotypes of human pegivirus-1 (HPgV-1) and three types of torque teno viruses (TTV-3, -16, and -22) in Brazilian patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Plasma samples from 20 patients were collected at three time points: pretransplantation (D+0), 30 days post-transplantation (D+30), and 100 days post-transplantation (D+100). We conducted longitudinal screening for HPgV-1 and three TTV variants using real-time PCR, comparing cycle threshold values across these intervals.ResultsThe overall HPgV-1 RNA prevalence at all collection points was 45% (n = 9/20), with all infected individuals carrying genotype 2. HPgV-1 infections exhibited stable, closely related strains over time, though virus evolution was highly individualized. The overall prevalence of TTV types was 5% for TTV-3, 30% for TTV-16, and 60% for TTV-22. Notably, all commensal viruses showed a decrease in cycle threshold at D+100, indicating a possible increase in viral load.ConclusionThese findings underscore the importance of commensal viruses in the context of HSCT and suggest their potential role as biomarkers for immune suppression and transplantation outcomes. Further research is warranted to elucidate their implications. image (AU) | |
| Processo FAPESP: | 21/11944-6 - Contínuo aprimoramento de vacinas: Centro para Vigilância Viral e Avaliação Sorológica (CeVIVAS) |
| Beneficiário: | Sandra Coccuzzo Sampaio Vessoni |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Ciência para o Desenvolvimento |
| Processo FAPESP: | 17/23205-8 - Avaliação do impacto de vírus emergentes e re-emergentes em hemoterapia e transplante de células-tronco por meio de técnicas moleculares avançadas |
| Beneficiário: | Svetoslav Nanev Slavov |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |