| Texto completo | |
| Autor(es): |
Alves-Silva, Milena Santos
;
Alves, Mariana Leite
;
Andrade-Oliveira, Vinicius
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CURRENT TOPICS IN MEDICINAL CHEMISTRY; v. N/A, p. 23-pg., 2025-07-17. |
| Resumo | |
Tissue-Resident Macrophages (TRMs) are essential cells of the immune system, strategically located in barrier tissues such as the skin, lungs, and intestines. They can originate from progenitor cells in the yolk sac and fetal liver, developing distinct features that enable them to respond effectively to local challenges and maintain tissue homeostasis. The functional plasticity of TRMs allows them to adapt to diverse microenvironments, facilitating their roles in tissue repair, inflammation, and immune surveillance. Recent studies have highlighted the potential of Natural Compounds (NCs) to modulate macrophage function, offering promising therapeutic strategies for managing inflammatory diseases. These compounds have been shown to enhance or suppress specific macrophage activities, influencing immune responses and promoting healing processes. This review highlights the importance of understanding TRMs and the role of natural compounds in modulating TRM activation and function. Deciphering the potential of NCs in macrophages may shed light on the development of innovative treatments for various immune-related diseases. (AU) | |
| Processo FAPESP: | 19/14755-0 - Modulação da microbiota intestinal e do sistema imune pelas células epiteliais intestinais: da homeostase tecidual às doenças |
| Beneficiário: | Vinicius de Andrade Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |