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| Autor(es): Mostrar menos - |
Pela, Vinicius Taioqui
;
Taira, Even Akemi
;
Ferrari, Carolina Ruis
;
Ventura, Talita Mendes Oliveira
;
Thomassian, Larissa Tercilia Grizzo
;
Henrique-Silva, Flavio
;
Carvalho, Thiago Saads
;
Fuentes, Andrea Soares da Costa
;
Fan, Karina
;
Marchetto, Reinaldo
;
Lussi, Adrian
;
Buzalaf, Marilia Afonso Rabelo
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Dentistry; v. 163, p. 10-pg., 2025-12-01. |
| Resumo | |
Objective: This study investigated the effectiveness of orally disintegrating films (ODFs) formulated with different proteins and peptide in minimizing early-stage dental erosion in vivo. Methods: Twelve individuals participated in a six-phase crossover: placebo, 1 mg sodium fluoride (NaF), 1 mg sugarcane-derived cystatin (CaneCPI-5), 5 mg maquiberry-derived cystatin (MaquiCPI-3), 1 mg orange-derived cystatin (CsinCPI-2), and 0.37 mg statherin peptide (StN15pSpS). Following prophylaxis, participants placed the ODFs on their tongues until they dissolved, after the acquired pellicle was allowed to form over 2 h. An erosive challenge (biopsy, 1 % citric acid, 15 s) was conducted on the labial surface of the maxillary central incisors. Enamel loss was assessed using Relative Surface Reflection Intensity (%SRI), and calcium release in citric acid was measured using Arsenazo-III. Data were analyzed using Kruskal-Wallis and Dunn's post hoc tests (p < 0.05). A questionnaire assessed participants' satisfaction and any side effects. Results: The %SRI results demonstrated that MaquiCPI-3, CaneCPI-5, StN15pSpS, and NaF provided significantly greater enamel protection compared to the placebo (p < 0.05). Calcium analysis showed that the ODFs containing CaneCPI-5 and MaquiCPI-3 resulted in similarly high calcium levels, whereas the placebo and NaF groups exhibited the lowest values, with no difference between them. The CsinCPI-2 and StN15pSpS groups displayed intermediate effects, with no significant differences compared to the other groups, except for CsinCPI-2, which presented significantly reduced calcium levels compared to the MaquiCPI-3 group (p < 0.05). Participants reported satisfaction with the taste of the ODFs, found the procedures acceptable, and noted no adverse effects. Conclusions: ODFs containing MaquiCPI-3, CaneCPI-5, and StN15pSpS effectively inhibited early dental erosion according to %SRI. (AU) | |
| Processo FAPESP: | 22/13268-0 - Avaliação do potencial protetor da CaneCPI-5, Stn15pSpS ou Hb, isolados ou combinados contra desafios erosivos in vivo: comparação entre soluções de bochecho e filmes orodispersíveis |
| Beneficiário: | Vinícius Taioqui Pelá |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/26070-1 - Modulação da película adquirida do esmalte e do biofilme para o controle da perda mineral dentária: desvendando mecanismos e possibilitando terapias |
| Beneficiário: | Marília Afonso Rabelo Buzalaf |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 23/11487-0 - Análise do efeito protetor de diferentes proteínas/peptídeo (CaneCPI-5, MaquiCPI-3, Estaterina e Hemoglobina) adicionados em filmes orodispersíveis para a prevenção da erosão dentária inicial in vivo |
| Beneficiário: | Gustavo Cassalate da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |