Analysis of vitamin D receptor gene polymorphisms in women with and without endometriosis

Autor(es)

Vilarino, Fabia Lima ^[1] ; Bianco, Bianca ^[1] ; Lerner, Tatiana Goberstein ^[1] ; Teles, Juliana Souto ^[1] ; Mafra, Fernanda Abani ^[1] ; Christofolini, Denise Maria ^[1] ; Barbosa, Caio Parente ^[1]

Afiliação do(s) autor(es)

^[1] ABC, Fac Med, Dept Gynecol & Obstet, Div Pathol Gynecol & Human Reprod, Santo Andre Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HUMAN IMMUNOLOGY; v. 72, n. 4, p. 359-363, APR 2011.
• Citações Web of Science: 22

Resumo

An aberrant immunologic mechanism has been suggested to be involved in the pathogenesis of endometriosis. Genetic alterations in the vitamin D receptor gene (VDR) may lead to important defects in gene activation that principally affect immune function. We have hypothesized a possible relationship between endometriosis and/or infertility and the VDR polymorphisms (Apal, Taql, Fokl, and Bats!). The study was a case-control study including 132 women with endometriosis-related infertility, 62 women with idiopathic infertility, and 133 controls. VDR polymorphisms were studied by restriction fragment length polymorphism. We found relatively similar VDR polymorphism genotype frequencies in cases and controls. When patients with minimal/mild and moderate/severe endometriosis were studied separately, no difference was found. When we compared infertile groups with and without endometriosis there was no statistically significant difference. The data suggest that VDR polymorphisms did not play an important role in the pathogenesis of endometriosis and/or infertility in the Brazilian women studied. (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 10/01104-6 - Estudo do polimorfismo Fok1 do gene VDR em mulheres portadoras de endometriose
• Beneficiário: Tatiana Goberstein Lerner
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 09/01960-2 - Estudo de polimorfismo do gene ptpn22 em mulheres portadoras de endometriose
• Beneficiário: Juliana Souto Teles
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 10/00459-5 - Estudo de polimorfismos do gene vdr em mulheres portadoras de endometriose
• Beneficiário: Caio Parente Barbosa
• Modalidade de apoio: Auxílio à Pesquisa - Regular