| Full text | |
| Author(s): |
Vilarino, Fabia Lima
[1]
;
Bianco, Bianca
[1]
;
Lerner, Tatiana Goberstein
[1]
;
Teles, Juliana Souto
[1]
;
Mafra, Fernanda Abani
[1]
;
Christofolini, Denise Maria
[1]
;
Barbosa, Caio Parente
[1]
Total Authors: 7
|
| Affiliation: | [1] ABC, Fac Med, Dept Gynecol & Obstet, Div Pathol Gynecol & Human Reprod, Santo Andre Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | HUMAN IMMUNOLOGY; v. 72, n. 4, p. 359-363, APR 2011. |
| Web of Science Citations: | 22 |
| Abstract | |
An aberrant immunologic mechanism has been suggested to be involved in the pathogenesis of endometriosis. Genetic alterations in the vitamin D receptor gene (VDR) may lead to important defects in gene activation that principally affect immune function. We have hypothesized a possible relationship between endometriosis and/or infertility and the VDR polymorphisms (Apal, Taql, Fokl, and Bats!). The study was a case-control study including 132 women with endometriosis-related infertility, 62 women with idiopathic infertility, and 133 controls. VDR polymorphisms were studied by restriction fragment length polymorphism. We found relatively similar VDR polymorphism genotype frequencies in cases and controls. When patients with minimal/mild and moderate/severe endometriosis were studied separately, no difference was found. When we compared infertile groups with and without endometriosis there was no statistically significant difference. The data suggest that VDR polymorphisms did not play an important role in the pathogenesis of endometriosis and/or infertility in the Brazilian women studied. (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 10/01104-6 - Study of Fok1 polymorphism of VDR gene in women with endometriosis |
| Grantee: | Tatiana Goberstein Lerner |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 09/01960-2 - STUDY OF PTPN22 GENE POLYMORPHISM IN WOMEN WITH ENDOMETRIOSIS |
| Grantee: | Juliana Souto Teles |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 10/00459-5 - Evaluation of VDR polymorphism in women with endometriosis |
| Grantee: | Caio Parente Barbosa |
| Support Opportunities: | Regular Research Grants |