| Texto completo | |
| Autor(es): |
de Souza de Azevedo, Pamela Oliveira
;
Nobrega Mendonca, Carlos Miguel
;
Ramos Moreno, Ana Carolina
;
Iank Bueno, Antonio Vinicius
;
Yokomizo de Almeida, Sonia Regina
;
Seibert, Liane
;
Converti, Attilio
;
Watanabe, Ii-Sei
;
Gierus, Martin
;
de Souza Oliveira, Ricardo Pinheiro
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 10, n. 1, p. 14-pg., 2020-07-23. |
| Resumo | |
Pediococcus pentosaceus LBM 18 has shown potential as producer of an antibacterial and antifungal bacteriocin-like inhibitory substance (BLIS). BLIS inhibited the growth of spoilage bacteria belonging to Lactobacillus, Enterococcus and Listeria genera with higher activity than Nisaplin used as control. It gave rise to inhibition halos with diameters from 9.70 to 20.00 mm, with Lactobacillus sakei being the most sensitive strain (13.50-20.00 mm). It also effectively suppressed the growth of fungi isolated from corn grain silage for up to 25 days and impaired morphology of colonies by likely affecting fungal membranes. These results point out that P. pentosaceus BLIS may be used as a new promising alternative to conventional antibacterial and antifungal substances, with potential applications in agriculture and food industry as a natural bio-controlling agent. Moreover, cytotoxicity and cell death induction tests demonstrated cytotoxicity and toxicity of BLIS to human colon adenocarcinoma Caco-2cells but not to peripheral blood mononuclear cells, with suggests possible applications of BLIS also in medical-pharmaceutical applications. (AU) | |
| Processo FAPESP: | 18/04385-8 - Construção de uma linhagem recombinante produtora de pediocina a partir de resíduo agroindustrial |
| Beneficiário: | Ricardo Pinheiro de Souza Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/25511-1 - Bioprospecção de bactérias probióticas bacteriocinogênicas: da otimização do cultivo à aplicação em sistemas de produção animal |
| Beneficiário: | Ricardo Pinheiro de Souza Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |