Airway epithelium mediates the anti-inflammatory effects of exercise on asthma

Autor(es)

Vieira, Rodolfo Paula ^{[1, 2]} ; de Toledo, Alessandra Choqueta ^[3] ; Ferreira, Sergio Cesar ^[4] ; Gomes dos Santos, Angela Batista ^[4] ; Rodrigues Medeiros, Maria Cristina ^[4] ; Hage, Marcia ^[4] ; Mauad, Thais ^[4] ; Martins, Milton de Arruda ^[3] ; Dolhnikoff, Marisa ^[4] ; Fernandes de Carvalho, Celso Ricardo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept Phys Therapy LIM 34, Sao Paulo - Brazil

^[2] Univ Hosp Freiburg, Dept Pneumol, COPD & Asthma Res Grp, Freiburg - Germany

^[3] Univ Sao Paulo, Sch Med, Dept Clin Med LIM 20, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Med, Dept Pathol LIM 05, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Respiratory Physiology & Neurobiology; v. 175, n. 3, p. 383-389, MAR 15 2011.
• Citações Web of Science: 41

Resumo

Airway epithelium plays an important role in the asthma physiopathology. Aerobic exercise decreases Th2 response in murine models of allergic asthma, but its effects on the structure and activation of airway epithelium in asthma are unknown. BALB/c mice were divided into control, aerobic exercise, ovalbumin-sensitized and ovalbumin-sensitized plus aerobic exercise groups. Ovalbumin sensitization occurred on days 0, 14, 28, 42, and aerosol challenge from day 21 to day 50. Aerobic exercise started on day 22 and ended on day 50. Total cells and eosinophils were reduced in ovalbumin-sensitized group submitted to aerobic exercise. Aerobic exercise also reduced the oxidative and nitrosative stress and the epithelial expression of Th2 cytokines, chemokines, adhesion molecules, growth factors and NF-kB and P2X7 receptor. Additionally, aerobic exercise increased the epithelial expression of IL-10 in non-sensitized and sensitized animals. These findings contribute to the understanding of the beneficial effects of aerobic exercise for chronic allergic airway inflammation, suggesting an immune-regulatory role of exercise on airway epithelium. (C) 2011 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 07/01026-2 - Avaliacao dos mecanismos envolvidos nos efeitos da atividade fisica aerobia em modelo experimental de inflamacao pulmonar alergica cronica.
• Beneficiário: Rodolfo de Paula Vieira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado