| Texto completo | |
| Autor(es): Mostrar menos - |
Sonego, Fabiane
;
Castanheira, Fernanda V. S.
;
Czaikoski, Paula G.
;
Kanashiro, Alexandre
;
Souto, Fabricio O.
;
Franca, Rafael O.
;
Nascimento, Daniele C.
;
Freitas, Andressa
;
Spiller, Fernando
;
Cunha, Larissa D.
;
Zamboni, Dario S.
;
Alves-Filho, Jose C.
;
Cunha, Fernando Q.
Número total de Autores: 13
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS One; v. 9, n. 8, p. 13-pg., 2014-08-01. |
| Resumo | |
Pathogen recognition and triggering of the inflammatory response following infection in mammals depend mainly on Toll like and Nod-like receptors. Here we evaluated the role of Nod1, Nod2 and MyD88-dependent signaling in the chemokine production and neutrophil recruitment to the infectious site during sepsis induced by cecal ligation and puncture (CLP) in C57BI/6 mice. We demonstrate that Nodi and Nod2 are not involved in the release of chemokines and recruitment of neutrophils to the infectious site during CLP-induced septic peritonitis because these events were similar in wild-type Nod Nod2-, Nod1/Nod2- and Rip2-deficient mice. Consequently, the local and systemic bacterial loads were not altered. Accordingly, her Nod1 nor Nod2 was involved in the production of he circulating cytokines and in the accumulation of leukocytes in By contrast, we showed that MyD88-dependent signaling is crucial for the establishment of the local inflammatory response during CLP-induced sepsis. MyD88-deficient mice were susceptible to sepsis because of an impaired local production chemokines and defective neutrophil recruitment to the infection site. Altogether, these data show that Nod1, Nod2 and Rip2 are not required for local chemokine production and neutrophil recruitment during CLP-Induced sepsis, and they importance of MyD88-dependent signaling for initiation of a protective host response. (AU) | |
| Processo FAPESP: | 08/11593-4 - Participaçao dos receptores tipo nod na gênese da resposta inflamatória durante a sepse polimicrobiana |
| Beneficiário: | Fabiane Sônego |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 11/19670-0 - Mecanismos envolvidos na fisiopatologia da artrite reumatóide, dor e sepse |
| Beneficiário: | Fernando de Queiroz Cunha |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |