| Texto completo | |
| Autor(es): Mostrar menos - |
Cataldo Lima, Julia
;
Araujo de Oliveira, Emily
;
de Mendonca Oliveira, Luana
;
Cristina Gozzi-Silva, Sarah
;
Calvielli Castelo Branco, Anna Claudia
;
Wesley Alberca Custodio, Ricardo
;
Grigoletto Fernandes, Iara
;
da Silva Duarte, Alberto Jose
;
Alves de Brito, Cyro
;
Sato, Maria Notomi
;
Pereira, Natalli Zanete
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FUTURE VIROLOGY; v. 20, n. 11, p. 8-pg., 2025-12-11. |
| Resumo | |
AimsThe severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic presents a major global health challenge. Innate immunity is a key defense against viral infections and influences disease progression. Similar to SARS-CoV-1, which can suppress interferon (IFN) production to evade the immune response, SARS-CoV-2 May also impair antiviral pathways.Materials and methodsTo investigate this, we analyzed the expression of interferon-stimulated genes (ISGs) in 48 SARS-CoV-2-infected patients using real-time polymerase chain reaction (RT-qPCR) and assessed toll-like receptor (TLR7) expression in blood cells via flow cytometry.Results and conclusionsResults showed that infected individuals had reduced baseline expression of antiviral factors and a diminished response to stimulation with a TLR7/8 agonist (CL097), compared to healthy individuals. A decrease in pattern recognition receptors (PRRs) was also observed at both the gene and protein levels. These findings support the hypothesis that SARS-CoV-2 disrupts the IFN signaling pathway, similar to SARS-CoV-1. Reduced expression of innate immune receptors appears to impair the production of antiviral molecules, potentially delaying viral clearance and worsening disease outcomes. This highlights the importance of innate immune regulation in SARS-CoV-2 infection and may help inform future therapeutic strategies. (AU) | |
| Processo FAPESP: | 19/25119-7 - Interface materno-fetal: imunopatogênese e intervenção vacinal em infecções virais |
| Beneficiário: | Maria Notomi Sato |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 20/15199-0 - Avaliação do papel dos receptores TLR 4 e TLR 7/8 em indivíduos infectados com SARS-CoV-2 |
| Beneficiário: | Julia Cataldo Lima |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |