Claudin expression is dysregulated in prostate adenocarcinomas but does not correlate with main clinicopathological parameters

Autor(es)

Coutinho-Camillo, Claudia Malheiros ^[1] ; Lourenco, Silvia Vanessa ^[2] ; da Fonseca, Francisco Paulo ^[3] ; Soares, Fernando Augusto ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Hosp AC Camargo Fund Antonio Prudente, Dept Anat Patol, BR-01509010 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Dent, Discipline Gen Pathol, Sao Paulo - Brazil

^[3] Hosp AC Camargo Fund Antonio Prudente, Div Urol, Dept Pelv Surg, BR-01509010 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PATHOLOGY; v. 43, n. 2, p. 143-148, FEB 2011.
• Citações Web of Science: 7

Resumo

Aims: Claudins, a large family of essential tight junction (TJ) proteins, are abnormally regulated in human carcinomas. The aim of this study was to determine the expression of claudins 1, 2, 3, 4, 5, 7, and 11 in prostate samples from Brazilian patients and correlate it with the clinicopathological features of prostate cancer. Methods: Using a tissue microarray (TMA) of specimens of prostate adenocarcinoma and benign prostatic hyperplasia (BPH) we analysed the expression of claudins 1, 2, 3, 4, 5, 7, and 11 by immunohistochemistry. Results: Claudin 4 was down-regulated and claudins 2, 3, and 5 were overexpressed in prostate adenocarcinomas compared with BPH samples. Expression of claudins 1 and 7 was similar in tumours and BPH samples. Claudin 11 was absent from all prostate samples. Overexpression of claudin 3 was associated with perineural invasion (p = 0.014) and tended to occur in advanced stages of the disease (p = 0.064). Increased expression of claudin 5 was marginally associated with perineural invasion (p = 0.060). Conclusions: Our results suggest that alterations in claudin expression occur in prostate cancer cells, although we have not found an association with the main clinicopathological parameters. (AU)

• Processo FAPESP: 98/14335-2 - Antonio Prudente Cancer Research Center
• Beneficiário: Fernando Augusto Soares
• Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs