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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey

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Autor(es):
Andersen, Monica L. [1] ; Alvarenga, Tathiana A. [1] ; Mazzotti, Diego R. [1] ; Guindalini, Camila [1] ; Pellegrino, Renata [1] ; Barrueco, Karina F. [1] ; Santos-Silva, Rogerio [1] ; Bittencourt, Lia R. [1] ; Tufik, Sergio [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Fertility and Sterility; v. 95, n. 2, p. 621-624, FEB 2011.
Citações Web of Science: 4
Resumo

Objective: To evaluate a potential association among the hormonal profile, PROGINS polymorphism, and erectile dysfunction (ED) complaints in a large population-based sample in Sao Paulo, Brazil. Design: Population-based questionnaire study. Setting: Interviews, sleep recording, and blood sample were conducted in a sleep institute. Patient(s): The total study participants included 467 men. Intervention(s): General information was obtained through interviews, and a blood sample was collected for hormone levels, DNA extraction, and PROGINS genotyping. Main Outcome Measure(s): The effect of progesterone and the PROGINS polymorphism on the risk of developing ED were measured by questionnaire and blood sample. Result(s): Progesterone, prolactin, testosterone, and estradiol levels did not differ between the genotype groups (T1/T1 and T1/T2+T2/T2). No significant genotypic or allelic differences were found between individuals with ED complaints and controls. Multivariate logistic regression analyses including age, body mass index, hypertension, diabetes, apnea-hypopnea index, and genetic ancestry estimation, as well as the PROGINS polymorphism, confirmed the lack of association between the T2 allele carriers and the risk of ED(odds ratio = 0.80; 95% confidence interval = 0.40-1.62). Conclusion(s): This is the first study to demonstrate the genotypic and allelic frequencies of the PROGINS polymorphism in a large population-based sample of men. The results do not support a direct role for the PROGINS polymorphism in the risk of developing ED; however, further examination of other variants within PR gene will be necessary to completely rule out an effect. (Fertil Steril (R) 2011;95:621-4. (C) 2011 by American Society for Reproductive Medicine.) (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 07/50525-1 - Epidemiologia do sono na cidade de São Paulo - Episono 2007
Beneficiário:Rogério Santos da Silva
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 09/01030-5 - Efeito da privação e restrição de sono na função reprodutiva de ratos machos
Beneficiário:Tathiana Aparecida Fernandes de Alvarenga
Linha de fomento: Bolsas no Brasil - Doutorado