Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey

Author(s)

Andersen, Monica L. ^[1] ; Alvarenga, Tathiana A. ^[1] ; Mazzotti, Diego R. ^[1] ; Guindalini, Camila ^[1] ; Pellegrino, Renata ^[1] ; Barrueco, Karina F. ^[1] ; Santos-Silva, Rogerio ^[1] ; Bittencourt, Lia R. ^[1] ; Tufik, Sergio ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil

• Document type: Journal article
• Source: Fertility and Sterility; v. 95, n. 2, p. 621-624, FEB 2011.
• Web of Science Citations: 4

Abstract

Objective: To evaluate a potential association among the hormonal profile, PROGINS polymorphism, and erectile dysfunction (ED) complaints in a large population-based sample in Sao Paulo, Brazil. Design: Population-based questionnaire study. Setting: Interviews, sleep recording, and blood sample were conducted in a sleep institute. Patient(s): The total study participants included 467 men. Intervention(s): General information was obtained through interviews, and a blood sample was collected for hormone levels, DNA extraction, and PROGINS genotyping. Main Outcome Measure(s): The effect of progesterone and the PROGINS polymorphism on the risk of developing ED were measured by questionnaire and blood sample. Result(s): Progesterone, prolactin, testosterone, and estradiol levels did not differ between the genotype groups (T1/T1 and T1/T2+T2/T2). No significant genotypic or allelic differences were found between individuals with ED complaints and controls. Multivariate logistic regression analyses including age, body mass index, hypertension, diabetes, apnea-hypopnea index, and genetic ancestry estimation, as well as the PROGINS polymorphism, confirmed the lack of association between the T2 allele carriers and the risk of ED(odds ratio = 0.80; 95% confidence interval = 0.40-1.62). Conclusion(s): This is the first study to demonstrate the genotypic and allelic frequencies of the PROGINS polymorphism in a large population-based sample of men. The results do not support a direct role for the PROGINS polymorphism in the risk of developing ED; however, further examination of other variants within PR gene will be necessary to completely rule out an effect. (Fertil Steril (R) 2011;95:621-4. (C) 2011 by American Society for Reproductive Medicine.) (AU)

• FAPESP's process: 09/01030-5 - Effect of sleep deprivation and sleep restriction on the reproductive function of male rats
• Grantee: Tathiana Aparecida Fernandes de Alvarenga
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 98/14303-3 - Center for Sleep Studies
• Grantee: Sergio Tufik
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC