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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey

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Author(s):
Andersen, Monica L. [1] ; Alvarenga, Tathiana A. [1] ; Mazzotti, Diego R. [1] ; Guindalini, Camila [1] ; Pellegrino, Renata [1] ; Barrueco, Karina F. [1] ; Santos-Silva, Rogerio [1] ; Bittencourt, Lia R. [1] ; Tufik, Sergio [1]
Total Authors: 9
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Fertility and Sterility; v. 95, n. 2, p. 621-624, FEB 2011.
Web of Science Citations: 4
Abstract

Objective: To evaluate a potential association among the hormonal profile, PROGINS polymorphism, and erectile dysfunction (ED) complaints in a large population-based sample in Sao Paulo, Brazil. Design: Population-based questionnaire study. Setting: Interviews, sleep recording, and blood sample were conducted in a sleep institute. Patient(s): The total study participants included 467 men. Intervention(s): General information was obtained through interviews, and a blood sample was collected for hormone levels, DNA extraction, and PROGINS genotyping. Main Outcome Measure(s): The effect of progesterone and the PROGINS polymorphism on the risk of developing ED were measured by questionnaire and blood sample. Result(s): Progesterone, prolactin, testosterone, and estradiol levels did not differ between the genotype groups (T1/T1 and T1/T2+T2/T2). No significant genotypic or allelic differences were found between individuals with ED complaints and controls. Multivariate logistic regression analyses including age, body mass index, hypertension, diabetes, apnea-hypopnea index, and genetic ancestry estimation, as well as the PROGINS polymorphism, confirmed the lack of association between the T2 allele carriers and the risk of ED(odds ratio = 0.80; 95% confidence interval = 0.40-1.62). Conclusion(s): This is the first study to demonstrate the genotypic and allelic frequencies of the PROGINS polymorphism in a large population-based sample of men. The results do not support a direct role for the PROGINS polymorphism in the risk of developing ED; however, further examination of other variants within PR gene will be necessary to completely rule out an effect. (Fertil Steril (R) 2011;95:621-4. (C) 2011 by American Society for Reproductive Medicine.) (AU)

FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 09/01030-5 - Effect of sleep deprivation and sleep restriction on the reproductive function of male rats
Grantee:Tathiana Aparecida Fernandes de Alvarenga
Support type: Scholarships in Brazil - Doctorate