Copulatory efficiency and fertility in male rats exposed perinatally to flutamide

Autor(es)

Leonelli, Carina ^[1] ; Garcia, Patricia C. ^[2] ; Pereira, Oduvaldo C. M. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Inst Biosci, Dept Pharmacol, BR-18618970 Sao Paulo - Brazil

^[2] UNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Internal Med, BR-18618970 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 31, n. 1, p. 10-16, JAN 2011.
• Citações Web of Science: 8

Resumo

This study investigated the effects of perinatal treatment with flutamide on male sexual behavior, semen parameters, and fertility in adult male rats. Pregnant rats received 15 mg/kg of flutamide or peanut oil, s.c., at days 19 and 22 of pregnancy and for the first five postnatal days. Treated male offspring showed increases in latency to copulatory behavior, number of mounts without penis intromission, number of intromissions until ejaculation, latency to ejaculation, and reduced number of ejaculations. Flutamide treated rats presented reductions in weight of testes and prostate, percentage of normal spermatozoa, spermatozoa concentration, testicular sperm production, and testosterone level. Normal females mated with treated males presented more pre-implantation losses, reduced implantation rates, and consequently reduced offspring size. The results indicated that perinatal flutamide treatment damaged organizational processes of sexual differentiation, which led to inefficiency in copulatory behavior and reductions in sperm quality and count, resulting in low capacity for producing descendants. (C) 2010 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 07/57521-1 - Flutamida no periodo perinatal: repercussao tardia em aspectos reprodutivos de ratos machos.
• Beneficiário: Carina Leonelli
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 06/57038-6 - Influencia da exposicao pre-natal a betametasona sobre o desenvolvimento da prole, do nascimento a vida adulta reproudutiva, em ratos.
• Beneficiário: Oduvaldo Câmara Marques Pereira
• Modalidade de apoio: Auxílio à Pesquisa - Regular