Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats

Autor(es):Mostrar menos -

Herrera, Bruno S. ; Martins-Porto, Rodrigo ; Campi, Paula ; Holzhausen, Marinella ^[1] ; Teixeira, Simone A. ; Mendes, Gustavo D. ; Costa, Soraia K. P. ; Gyurko, Robert ^[2] ; Van Dyke, Thomas E. ^[2] ; Spolidorio, Luis C. ^[3] ; Muscara, Marcelo N. ^[4]

Afiliação do(s) autor(es)

^[1] FOUSP, Dept Stomatol, Sao Paulo - Brazil

^[2] Boston Univ, Dept Periodontol & Oral Biol, Boston, MA 02215 - USA

^[3] UNESP, FOAr, Dept Physiol & Pathol, Araraquara, SP - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, ICB, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 56, n. 1, p. 41-47, JAN 2011.
• Citações Web of Science: 15

Resumo

Objective: In this study we have assessed the renal and cardiac consequences of ligature-induced periodontitis in both normotensive and nitric oxide (NO)-deficient (L-NAME-treated) hypertensive rats. Materials and methods: Oral L-NAME (or water) treatment was started two weeks prior to induction of periodontitis. Rats were sacrificed 3, 7 or 14 days after ligature placement, and alveolar bone loss was evaluated radiographically. Thiobarbituric reactive species (TBARS; a lipid peroxidation index), protein nitrotyrosine (NT; a marker of protein nitration) and myeloperoxidase activity (MPO; a neutrophil marker) were determined in the heart and kidney. Results: In NO-deficient hypertensive rats, periodontitis-induced alveolar bone loss was significantly diminished. In addition, periodontitis-induced cardiac NT elevation was completely prevented by L-NAME treatment. On the other hand L-NAME treatment enhanced MPO production in both heart and kidneys of rats with periodontitis. No changes due to periodontitis were observed in cardiac or renal TBARS content. Conclusions: In addition to mediating alveolar bone loss, NO contributes to systemic effects of periodontitis in the heart and kidney. (C) 2010 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 02/00300-0 - Expressao e caracterizacao de inibidores endogenos da enzima oxido nitrico sintase em modelos animais de patologias envolvendo alteracoes na producao de oxido nitrico.
• Beneficiário: Marcelo Nicolas Muscara
• Modalidade de apoio: Auxílio à Pesquisa - Regular