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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats

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Herrera, Bruno S. ; Martins-Porto, Rodrigo ; Campi, Paula ; Holzhausen, Marinella [1] ; Teixeira, Simone A. ; Mendes, Gustavo D. ; Costa, Soraia K. P. ; Gyurko, Robert [2] ; Van Dyke, Thomas E. [2] ; Spolidorio, Luis C. [3] ; Muscara, Marcelo N. [4]
Total Authors: 11
Affiliation:
[1] FOUSP, Dept Stomatol, Sao Paulo - Brazil
[2] Boston Univ, Dept Periodontol & Oral Biol, Boston, MA 02215 - USA
[3] UNESP, FOAr, Dept Physiol & Pathol, Araraquara, SP - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, ICB, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 56, n. 1, p. 41-47, JAN 2011.
Web of Science Citations: 15
Abstract

Objective: In this study we have assessed the renal and cardiac consequences of ligature-induced periodontitis in both normotensive and nitric oxide (NO)-deficient (L-NAME-treated) hypertensive rats. Materials and methods: Oral L-NAME (or water) treatment was started two weeks prior to induction of periodontitis. Rats were sacrificed 3, 7 or 14 days after ligature placement, and alveolar bone loss was evaluated radiographically. Thiobarbituric reactive species (TBARS; a lipid peroxidation index), protein nitrotyrosine (NT; a marker of protein nitration) and myeloperoxidase activity (MPO; a neutrophil marker) were determined in the heart and kidney. Results: In NO-deficient hypertensive rats, periodontitis-induced alveolar bone loss was significantly diminished. In addition, periodontitis-induced cardiac NT elevation was completely prevented by L-NAME treatment. On the other hand L-NAME treatment enhanced MPO production in both heart and kidneys of rats with periodontitis. No changes due to periodontitis were observed in cardiac or renal TBARS content. Conclusions: In addition to mediating alveolar bone loss, NO contributes to systemic effects of periodontitis in the heart and kidney. (C) 2010 Elsevier Ltd. All rights reserved. (AU)