Age-related changes during a paradigm of chronic sleep restriction

Autor(es)

de Souza, Luciane ^[1] ; Andersen, Monica L. ^[1] ; Smaili, Soraya S. ^[2] ; Lopes, Guiomar S. ^[2] ; Ho, Priscila S. ^[1] ; Papale, Ligia A. ^[1] ; Tufik, Sergio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Farmacol, BR-04044020 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Behavioural Brain Research; v. 214, n. 2, p. 201-205, DEC 10 2010.
• Citações Web of Science: 4

Resumo

Fragmented and restricted sleep is a common problem for the human elderly. There is evidence that aging impairs sleep in animals as well. After sleep deprivation, older animals have less sleep rebound. Despite increasing complaints of reduced time for sleep in contemporary society, few studies have examined chronic sleep restriction protocols in animals. Therefore, the aim of the present study was to evaluate the effects of chronic sleep restriction on the sleep patterns of aged rats. Using the single platform method, 22-month-old male rats were submitted to 18 h of sleep restriction followed by 6 h of total sleep opportunity. The sleep-wake cycles of these rats were recorded for 6 h/day throughout the 12-day procedure. The results showed that total sleep time and NREM sleep were reduced during the 12-day sleep restriction period. However, rebound REM sleep was only significant on day 6. A negative rebound was also seen, particularly during the last days of the chronic sleep restriction period. Furthermore, sleep latency and mean wake bout length progressively increased during the protocol. These findings indicate that older rats have an inability to restore their sleep patterns during extended sleep deprivation. (C) 2010 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 08/50424-3 - Efeitos da restricao cronica de sono e do envelhecimento sobre a sinalizacao celular e apoptose de celulas do tecido nervoso.
• Beneficiário: Luciane de Souza
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs