Haemodynamic, metabolic and neuro-humoral abnormalities in young normotensive women at high familial risk for hypertension

Autor(es)

Ciolac, E. G. ^{[1, 2, 3]} ; Bocchi, E. A. ^[1] ; Bortolotto, L. A. ^[1] ; Carvalho, V. O. ^[4] ; Greve, J. M. D. ^[2] ; Guimaraes, G. V. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] HCFMUSP, Inst Heart, BR-05403010 Sao Paulo - Brazil

^[2] HCFMUSP, Inst Ortopedia & Traumatol, Lab Kinesiol, BR-05403010 Sao Paulo - Brazil

^[3] CEPEUSP, Lab Phys Act & Hlth, Sao Paulo - Brazil

^[4] HCFMUSP, Inst Crianca, Genet Unit, BR-05403010 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF HUMAN HYPERTENSION; v. 24, n. 12, p. 814-822, DEC 2010.
• Citações Web of Science: 18

Resumo

We analysed the haemodynamic, metabolic and hormonal status at rest and in response to exercise, in young normotensive women with two hypertensive parents (FH+ +; n=17; 25.1+/-4.8 years), one hypertensive parent (FH+; n=18; 24.9+/-4.1 years) and normotensive parents (FH-; n=15; 25.3+/-3.8 years). Casual and ambulatorial blood pressure (BP), carotid-femoral pulse wave velocity (PWV) and biochemistry were analysed. BP, nor-epinephrine (NE), epinephrine (EPI), endothelin-1 (ET-1) and nitrite/nitrate (NOx) levels were also analysed during a graded exercise test (GXT). Casual and ambulatorial BP were not different between groups, but PWV was 7.5 and 12.6% higher in FH+ + than FH+ and FH-, respectively, and 4.8% higher in FH+ than FH- (P <= 0.01). Insulin and insulin-to-glucose ratio were increased in FH+ + and FH+ (P<0.05), and low-density lipoprotein (LDL)-cholesterol tended to be higher only in FH+ + (P=0.07). FH+ + showed higher exercise and recovery diastolic BP and EPI levels, and increased resting, exercise and recovery NE, and ET-1 levels than FH- (P<0.05). FH+ showed only greater resting, exercise and recovery NE, and rest ET-1 (P<0.05). Resting, exercise and recovery NOx were lower in FH+ + and FH+ than FH- (P<0.01). Haemodynamic, metabolic and hormonal abnormalities were presented in nonhypertensive young women offspring of hypertensive parents before any increase in BP. Greater abnormalities were observed in women with a strong family history of hypertension (FH+ +). These results suggest that there is an early vascular, metabolic and hormonal involvement in a familial hypertensive disorder. Journal of Human Hypertension (2010) 24, 814-822; doi:10.1038/jhh.2010.21; published online 18 March 2010 (AU)

• Processo FAPESP: 04/00568-8 - Comportamento da pressão e complacência arterial sistêmica, secreção de óxido nítrico e endotelina-1, resistência à insulina e atividade do sistema nervoso simpático em normotensos filhos de hipertensos versus normotensos filhos de normotensos antes e após 16 semanas de atividade física contínua ou atividade física intervalada: estudo randomizado
• Beneficiário: Edimar Alcides Bocchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular