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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Haemodynamic, metabolic and neuro-humoral abnormalities in young normotensive women at high familial risk for hypertension

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Author(s):
Ciolac, E. G. [1, 2, 3] ; Bocchi, E. A. [1] ; Bortolotto, L. A. [1] ; Carvalho, V. O. [4] ; Greve, J. M. D. [2] ; Guimaraes, G. V. [1, 3]
Total Authors: 6
Affiliation:
[1] HCFMUSP, Inst Heart, BR-05403010 Sao Paulo - Brazil
[2] HCFMUSP, Inst Ortopedia & Traumatol, Lab Kinesiol, BR-05403010 Sao Paulo - Brazil
[3] CEPEUSP, Lab Phys Act & Hlth, Sao Paulo - Brazil
[4] HCFMUSP, Inst Crianca, Genet Unit, BR-05403010 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF HUMAN HYPERTENSION; v. 24, n. 12, p. 814-822, DEC 2010.
Web of Science Citations: 18
Abstract

We analysed the haemodynamic, metabolic and hormonal status at rest and in response to exercise, in young normotensive women with two hypertensive parents (FH+ +; n=17; 25.1+/-4.8 years), one hypertensive parent (FH+; n=18; 24.9+/-4.1 years) and normotensive parents (FH-; n=15; 25.3+/-3.8 years). Casual and ambulatorial blood pressure (BP), carotid-femoral pulse wave velocity (PWV) and biochemistry were analysed. BP, nor-epinephrine (NE), epinephrine (EPI), endothelin-1 (ET-1) and nitrite/nitrate (NOx) levels were also analysed during a graded exercise test (GXT). Casual and ambulatorial BP were not different between groups, but PWV was 7.5 and 12.6% higher in FH+ + than FH+ and FH-, respectively, and 4.8% higher in FH+ than FH- (P <= 0.01). Insulin and insulin-to-glucose ratio were increased in FH+ + and FH+ (P<0.05), and low-density lipoprotein (LDL)-cholesterol tended to be higher only in FH+ + (P=0.07). FH+ + showed higher exercise and recovery diastolic BP and EPI levels, and increased resting, exercise and recovery NE, and ET-1 levels than FH- (P<0.05). FH+ showed only greater resting, exercise and recovery NE, and rest ET-1 (P<0.05). Resting, exercise and recovery NOx were lower in FH+ + and FH+ than FH- (P<0.01). Haemodynamic, metabolic and hormonal abnormalities were presented in nonhypertensive young women offspring of hypertensive parents before any increase in BP. Greater abnormalities were observed in women with a strong family history of hypertension (FH+ +). These results suggest that there is an early vascular, metabolic and hormonal involvement in a familial hypertensive disorder. Journal of Human Hypertension (2010) 24, 814-822; doi:10.1038/jhh.2010.21; published online 18 March 2010 (AU)