Assessment of adiposity indexes and phase angle to predict metabolic disorders and cardiovascular risk in HIV seropositive patientes

• Grant number: 16/14698-8
• Support Opportunities: Regular Research Grants
• Duration: December 01, 2016 - November 30, 2018
• Field of knowledge: Health Sciences - Nutrition
• Principal Investigator: Maria Cristina Foss de Freitas
• Grantee: Maria Cristina Foss de Freitas
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Giovanna Soler Donofre ; Rebeca Antunes Beraldo

Abstract

Intoduction : The body fat redistribution and metabolic abnormalities found in HIV-infected patients on antiretroviral therapy high (HAART) and in Dunnigan-type familial partial lipodystrophy(FPLD) contribute to an atherogenic profile , increasing the risk for developing cardiovascular disease . Identify early risk for developing these diseases by practical , affordable , accurate and reliable methods of assessment used in clinical practice becomes fundamental. Objectives : To evaluate measures and indices of adiposity and associated bridges to propose cardiovascular risk in HIV-infected patients on ART in both sexes and in women with FPLD. Methods: 450 HIV positive patients on ART and 25 women with FPLD will be evaluated. We will measure circumferences (waist , hip, thigh, calf , neck, trunk ) , skinfolds ( biceps, triceps , subscapular , suprailiac ) conducted the examination of impedance analysis bioelectrical ( BIA ) and calculated indices of adiposity ( body mass index , waist ratio hip, waist thigh ratio , waist ratio calf , the waist height , body mass index corrected for body fat mass , body adiposity index , conicity index and body shape index) and calculate the phase angle using BIA. To identifying risk / cardiovascular events, we will conduct exams of electrocardiogram; stress electrocardiography; ankle brachial index test; pressure arterial hypertension , lipid biochemical tests and blood glucose. For insulin sensitivity assessment we will realize the basal insulin tests and calculate HOMA model (homeostasis model assessment of insulin resistance).To evaluate the performance of all measurements / indices of adiposity to predict cardiovascular risk will be used to ROC curves , and measures / indices that show better performance ( area under the curve) will be used to propose cutoff points ( which have better combinations of sensitivity / specificity) . (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BERALDO, REBECA A.; MELISCKI, GABRIELA C.; SILVA, BRUNA R.; NAVARRO, ANDERSON M.; BOLLELA, VALDES R.; SCHMIDT, ANDRE; FOSS-FREITAS, MARIA C.. Anthropometric measures of central adiposity are highly concordant with predictors of cardiovascular disease risk in HIV patients. AMERICAN JOURNAL OF CLINICAL NUTRITION, v. 107, n. 6, p. 883-893, JUN 2018. (16/14698-8, 13/23287-3)