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Assessment and proposed cutoffs for adiposity indices to predict cardiovascular risk in HIV-infected patients on antiretroviral therapy

Grant number: 13/23287-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2014
Effective date (End): March 31, 2017
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Maria Cristina Foss de Freitas
Grantee:Rebeca Antunes Beraldo
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Intoduction : The body fat redistribution and metabolic abnormalities found in HIV-infected patients on antiretroviral therapy high (HAART) contribute to an atherogenic profile , increasing the risk for developing cardiovascular disease . Identify early risk for developing these diseases by practical , affordable , accurate and reliable methods of assessment used in clinical practice becomes fundamental. Objectives : To evaluate measures and indices of adiposity and associated bridges to propose cardiovascular risk in HIV-infected patients on ART in both sexes . Methods: 450 HIV positive patients on ART will be evaluated. We will measure circumferences (waist , hip, thigh, calf , neck, trunk ) , skinfolds ( biceps, triceps , subscapular , suprailiac ) conducted the examination of impedance analysis bioelectrical ( BIA ) and calculated indices of adiposity ( body mass index , waist ratio hip, waist thigh ratio , waist ratio calf , the waist height , body mass index corrected for body fat mass , body adiposity index , conicity index and body shape index) . To identifying risk / cardiovascular events, we will conduct exams of electrocardiogram; stress electrocardiography; ankle brachial index test; pressure arterial hypertension , lipid biochemical tests and blood glucose. To evaluate the performance of all measurements / indices of adiposity to predict cardiovascular risk will be used to ROC curves , and measures / indices that show better performance ( area under the curve) will be used to propose cutoff points ( which have better combinations of sensitivity / specificity) .

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BERALDO, REBECA ANTUNES; MELISCKI, GABRIELA CRISTINA; SILVA, BRUNA RAMOS; NAVARRO, ANDERSON MARLIERE; BOLLELA, VALDES ROBERTO; SCHMIDT, ANDRE; FOSS-FREITAS, MARIA CRISTINA. Comparing the Ability of Anthropometric Indicators in Identifying Metabolic Syndrome in HIV Patients. PLoS One, v. 11, n. 2, . (13/23287-3)
BERALDO, REBECA A.; MELISCKI, GABRIELA C.; SILVA, BRUNA R.; NAVARRO, ANDERSON M.; BOLLELA, VALDES R.; SCHMIDT, ANDRE; FOSS-FREITAS, MARIA C.. Anthropometric measures of central adiposity are highly concordant with predictors of cardiovascular disease risk in HIV patients. AMERICAN JOURNAL OF CLINICAL NUTRITION, v. 107, n. 6, p. 883-893, . (16/14698-8, 13/23287-3)

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