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Effects of a lifestyle modification program on the metabolic, molecular and inflamattory profile of HIV patients with increased cardiovascular risk

Grant number: 17/00692-0
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2017
Effective date (End): October 31, 2020
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Maria Cristina Foss de Freitas
Grantee:Rebeca Antunes Beraldo
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The adverse effects of antiretroviral therapy (fat redistribution and metabolic changes) combined with chronic inflammation caused by the virus contribute to an atherogenic metabolic profile of HIV patients, disproportionately increasing cardiovascular diseases as a cause of death. Non-pharmacological strategies seem to have a more important effect in the treatment of metabolic alterations, besides not having adverse effects. No previous study evaluated the efficacy of a lifestyle modification program in improving the metabolic, molecular and inflammatory profile of HIV patients. Thus, the aim of the present study is to determine the ability of a lifestyle modification program to improve metabolic profile and prevent cardiovascular disease in HIV patients. With potential results for the prevention of cardiovascular complications, we expect to achieve a 5-point improvement in the Framinghan Risk Score at the end of the intervention. It is a randomized clinical trial. We will evaluate sixty patients (30 interventions and 30 controls) with increased cardiovascular risk. The program will last 24 weeks and will be coordinated by a nutritionist with the collaboration of a physical educator. The initial (before randomization) and final (after 24 weeks) evaluations consist of: body composition analysis, ankle brachial index examination, biochemical exams, systemic blood pressure, exercise electrocardiography, inflammatory cytokines, expression profile of genes associated with metabolism and cardiovascular risk, food and physical activity practice evaluation. Statistical analysis: t- Student's test (or non-parametric Mann-Whitney test) and chi-square test. A significance level of 5% will be considered.

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