TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients

Autor(es)

Silva, M. M. ^[1] ; Simoes, R. T. ^[2] ; Castelli, E. C. ^[2] ; Mendes-Junior, C. T. ^[3] ; Deghaide, N. H. S. ^[2] ; Tsuda, L. C. ^[1] ; Machado, A. A. ^[4] ; Donadi, E. A. ^[2] ; Fernandes, A. P. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Coll Nursing Ribeirao Preto, Dept Gen & Specialized Nursing, BR-14049902 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Div Clin Immunol, BR-05508 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Pret, BR-14040901 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, BR-05508 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF IMMUNOGENETICS; v. 37, n. 5, p. 379-385, OCT 2010.
• Citações Web of Science: 3

Resumo

P>The aim of this study was to evaluate the frequency of TNFa-e microsatellites and the promoter region (TNF-308 and TNF-238) in HIV/AIDS-infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case-control association study. Microsatellite and the TNF promoter region polymorphisms were amplified by PCR and submitted to polyacrylamide gel electrophoresis. The genotypes and allele frequencies for 67 HIV-positive patients with lipodystrophy were compared with 50 HIV-positive patients with no evidence of lipodystrophy and with 131 healthy HIV-negative individuals. The presence of the TNFa5 allele could provide HIV/AIDS patients with protection against developing LS. The presence of TNF-308G allele, as well as of its homozygote TNF-308GG, were associated with susceptibility to developing LS. In addition, the presence of the haplotype TNFe3-d3-238G-308A-c1-a5-b7 suggests protection against developing that syndrome. This study highlights that polymorphic sites spanning the region nearby the TNF locus are associated with LS development in HIV/AIDS patients. (AU)

• Processo FAPESP: 05/57087-4 - Polimorfismo do fator de necrose tumoral (TNF) na síndrome da lipodistrofia associada à terapia anti-retroviral em portadores do HIV-1
• Beneficiário: Mariana Machado da Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 04/08388-9 - Polimorfismo do fator de necrose tumoral na síndrome da lipodistrofia associada à terapia anti-retroviral em portadores do HIV-1
• Beneficiário: Ana Paula Morais Fernandes
• Modalidade de apoio: Auxílio à Pesquisa - Regular