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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients

Full text
Author(s):
Silva, M. M. [1] ; Simoes, R. T. [2] ; Castelli, E. C. [2] ; Mendes-Junior, C. T. [3] ; Deghaide, N. H. S. [2] ; Tsuda, L. C. [1] ; Machado, A. A. [4] ; Donadi, E. A. [2] ; Fernandes, A. P. M. [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Coll Nursing Ribeirao Preto, Dept Gen & Specialized Nursing, BR-14049902 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Div Clin Immunol, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Pret, BR-14040901 Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, BR-05508 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF IMMUNOGENETICS; v. 37, n. 5, p. 379-385, OCT 2010.
Web of Science Citations: 3
Abstract

P>The aim of this study was to evaluate the frequency of TNFa-e microsatellites and the promoter region (TNF-308 and TNF-238) in HIV/AIDS-infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case-control association study. Microsatellite and the TNF promoter region polymorphisms were amplified by PCR and submitted to polyacrylamide gel electrophoresis. The genotypes and allele frequencies for 67 HIV-positive patients with lipodystrophy were compared with 50 HIV-positive patients with no evidence of lipodystrophy and with 131 healthy HIV-negative individuals. The presence of the TNFa5 allele could provide HIV/AIDS patients with protection against developing LS. The presence of TNF-308G allele, as well as of its homozygote TNF-308GG, were associated with susceptibility to developing LS. In addition, the presence of the haplotype TNFe3-d3-238G-308A-c1-a5-b7 suggests protection against developing that syndrome. This study highlights that polymorphic sites spanning the region nearby the TNF locus are associated with LS development in HIV/AIDS patients. (AU)

FAPESP's process: 05/57087-4 - Polymorfism of the tumoral necrosis factor (TNF) in antiretroviral associated lipodystrophy syndrome in HIV-1-infected patients
Grantee:Mariana Machado da Silva
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 04/08388-9 - Polymorfism of the tumoral necrosis factor in antiretroviral associated lipodystrophy syndrome in HIV-1-infected patients
Grantee:Ana Paula Morais Fernandes
Support Opportunities: Regular Research Grants