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Influence of brown adipose tissue in energy metabolism of people living with HIV and AIDS

Grant number: 16/19155-2
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2017
Effective date (End): August 13, 2019
Field of knowledge:Health Sciences - Nutrition
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Anderson Marliere Navarro
Grantee:Mariana Palma Guimarães
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):17/26509-8 - Molecular and cellular bases of alterations in signaling cross-talk in relation to adipose and metabolic dysfunction, BE.EP.DR

Abstract

The power and effectiveness of antiretroviral therapies (ART) increased the life expectancy of HIV-infected patients. However, ART is associated with serious adverse events that include metabolic changes and abnormal redistribution of body fat, called HIV-associated lipodystrophy syndrome (HALS). Studies show that ART is associated with changes in adipose tissue biology that affect systemic metabolism, one of the important factors in the development of HALS. Adipose tissue might be divided into white adipose tissue, which stores triglycerides and has endocrine functions; and brown adipose tissue, which has thermogenic function and is associated with increased energy expenditure to protect against energy excess. Some studies have verified the presence of hypermetabolism in people living with HIV/AIDS, with lipodystrophy; however, the factors that lead to increased energy expenditure in this population remain undefined. Objective: to evaluate the influence of brown adipose tissue in energetic metabolism in people living with HIV and AIDS with lipodystrophy. Methods: the study will be conducted in Clinics Hospital of the Ribeirão Preto Medical School. We will evaluate 33 people divided into three groups: 1- HIV-infected people on ART, with lipodystrophy; 2- HIV-infected people on ART, without lipodystrophy; 3- Healthy people (control). We will evaluate: the quantity of brown tissue adipose by computed tomography, body composition by dual emission X-ray absorptiometry (DEXA), resting energy expenditure by indirect calorimetry, and biochemical analysis (glucose and lipid metabolism, adipokines and citokines). An adipose tissue sample of dorsocervical region will be collected for histo-pathological analysis. Statistical tests will be used to assess differences between the groups and the correlations between the variables of interest. (AU)

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