Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes

Autor(es)

Melo Pereira, Jose Clayston ^[1] ; Carregaro, Vanessa ^[2] ; Costa, Diego Luis ^[2] ; da Silva, Joao Santana ^[2] ; Cunha, Fernando Q. ^[3] ; Franco, Douglas Wagner ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Quim & Fis Mol, Inst Quim Sao Carlos, Sao Carlos, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; v. 45, n. 9, p. 4180-4187, SEP 2010.
• Citações Web of Science: 31

Resumo

The complexes trans-{[}Ru(NO)(NH(3))(4)L](X)(3) (X = BF(4)(-), PF(6)(-) or Cl(-) and L = N-heterocyclic ligands, P (OEt)(3), SO(3)(-2)), and {[}Ru(NO)Hedta)] were shown to exhibit IC(50pro) in the range of 36 (L = imN) to 5000 mu M (L = imC). The inhibitory effects of trans-{[}Ru(NO)(NH(3))(4)imN](BF(4))(3) and of the Angeli's salt on the growth of the intramacrophage amastigote form studied were found to be similar while the trans-{[}Ru(NH(3))(4)imN(H(2)O)](2+) complex was found not to exhibit any substantial antiamastigote effect. The trans-{[}Ru(NO)(NH(3))(4)imN](BF(4))(3) compound, administered (500 nmol kg(-1) day(-1)) in BALB/c mice infected with Leishmania major, was found to exhibit a 98% inhibition on the parasite growth. Furthermore, this complex proved to be at least 66 times more efficient than glucantime in in vivo experiments. (C) 2010 Elsevier Masson SAS. All rights reserved. (AU)

• Processo FAPESP: 06/53266-4 - Química, fotoquímica e aplicações biológicas de complexos de rutênio com óxido nítrico e assemelhados de solução a materiais
• Beneficiário: Elia Tfouni
• Modalidade de apoio: Auxílio à Pesquisa - Temático