| Texto completo | |
| Autor(es): Mostrar menos - |
Quincoces Suarez, Jose Agustin
[1]
;
Rando, Daniela Goncales
[2]
;
Santos, Reginaldo Pereira
[1]
;
Goncalves, Carolina Passarelli
[1]
;
Ferreira, Elizabeth
[2]
;
de Carvalho, Joao Ernesto
[3]
;
Kohn, Luciana
[3]
;
Maria, Durvanei Augusto
[4]
;
Faiao-Flores, Fernanda
[4]
;
Michalik, Dirk
[5]
;
Marcucci, Maria Cristina
[6]
;
Vogel, Christian
[7]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Bandeirante Sao Paulo UNIBAN, Organ Synth Lab, Sao Paulo - Brazil
[2] Univ Sao Paulo USP, LAPEN, Dept Pharm, Fac Pharmaceut Sci, Sao Paulo - Brazil
[3] Univ Estadual Campinas, UNICAMP, Div Pharmacol & Toxicol, Multidisciplinary Ctr Chem Biol & Agr, Campinas - Brazil
[4] Butantan Inst, Biochem & Biophys Lab, Sao Paulo - Brazil
[5] Leibniz Inst Katalyse, Rostock - Germany
[6] Univ Bandeirante Sao Paulo UNIBAN, Lab Nat Prod, Sao Paulo - Brazil
[7] Univ Rostock, Inst Chem, D-2500 Rostock 1 - Germany
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Bioorganic & Medicinal Chemistry; v. 18, n. 17, p. 6275-6281, SEP 1 2010. |
| Citações Web of Science: | 15 |
| Resumo | |
This paper describes a new method for the preparation of 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one 1 and its derivatives 2-5. This set of synthetic compounds exhibited high antitumoral activities regarding in vitro screening against several human tumor cell lines as lung carcinoma NCI-460, melanoma UACC-62, breast MCF-7, colon HT-29, renal 786-O, ovarian OVCAR-03 and ovarian expressing the resistance phenotype for adriamycin NCI-ADR/ RES, prostate PC-3, and leukemia K-562. Compounds were also tested against murine tumor cell line B16F10 melanoma and lymphocytic leukemia L1210 as well as to their effect toward normal macrophages. Specific activity against colon cancer cells HT-29 was observed for all tested compounds and suggests further studies with models of colon cancer. Compounds 1, 2, and 4 showed significant cytotoxic activity with IC(50) values <= 2.3 mu M for all human cancer cell lines. Intraperitoneal acute administration of compound 1 and 2 showed very low toxicity rate. (C) 2010 Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 06/00116-5 - Chalconas e N-acilidrazonas bioativas: análise estrutural comparativa por meio de estudos de QSAR e desenvolvimento de análogos otimizados |
| Beneficiário: | Daniela Goncales Galasse Rando |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 04/11351-0 - Sintese de heterociclos prenilados a partir de produtos naturais. |
| Beneficiário: | José Agustín Pablo Quincoces Suárez |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |