N-Methyl-D-aspartate glutamate receptors in the hypothalamic paraventricular nucleus modulate cardiac component of the baroreflex in unanesthetized rats

Autor(es)

Crestani, Carlos C. ^[1] ; Alves, Fernando H. F. ^[1] ; Busnardo, Cristiane ^[1] ; Resstel, Leonardo B. M. ^[1] ; Correa, Fernando M. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEUROSCIENCE RESEARCH; v. 67, n. 4, p. 317-326, AUG 2010.
• Citações Web of Science: 37

Resumo

In the present study, we investigated the role played by the hypothalamic paraventricular nucleus (PVN) in the modulation of cardiac baroreflex activity in unanesthetized rats. Bilateral microinjections of the nonselective neurotransmission blocker CoCl(2) into the PVN decreased the reflex bradycardic response evoked by blood pressure increases, but had no effect on reflex tachycardia evoked by blood pressure decreases. Bilateral microinjections of the selective NMDA glutamate receptor antagonist LY235959 into the PVN caused effects that were similar to those observed after microinjections of CoCl(2), decreasing reflex bradycardia without affecting tachycardic response. The microinjection of the selective non-NMDA glutamate receptor antagonist NBQX into the PVN did not affect the baroreflex activity. Also, the microinjection of L-glutamate into the PVN increased the reflex bradycardia, an effect opposed to that observed after PVN treatment with CoCl(2) or LY235959, and this effect of L-glutamate was blocked by PVN pretreatment with LY235959. LY235959 injected into the PVN after iv. treatment with the selective beta(1)-adrenoceptor antagonist atenolol still decreased the reflex bradycardia. Taken together, our results suggest a facilitatory influence of the PVN on the bradycardic response of the baroreflex through activation of local NMDA glutamate receptors and a modulation of the cardiac parasympathetic activity. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. (AU)

• Processo FAPESP: 06/52446-9 - Envolvimento do sistema glutamatergico dos nucleos paraventricular e supra optico na liberacao de vasopressina e ocitocina em ratos.
• Beneficiário: Cristiane Busnardo Santiago
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 06/57670-4 - Estudo da participação da neurotransmissão noradrenérgica do núcleo leito da estria terminal na regulação do sistema cardiovascular em ratos
• Beneficiário: Carlos Cesar Crestani
• Modalidade de apoio: Bolsas no Brasil - Doutorado