A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L.) infantum chagasi infection in the Brazilian Amazon region

Autor(es)

Silveira, Fernando T. ^{[1, 2]} ; Lainson, Ralph ^[2] ; Crescente, Jose Angelo ^[1] ; de Souza, Adelson A. A. ^[2] ; Campos, Marliane B. ^[2] ; Gomes, Claudia M. C. ^[3] ; Laurenti, Marcia D. ^[3] ; Corbett, Carlos E. P. ^[3]

Afiliação do(s) autor(es)

^[1] Fed Univ Para, Inst Trop Med, BR-66059 Belem, Para - Brazil

^[2] Minist Hlth, Evandro Chagas Inst, Dept Parasitol, BR-66090000 Belem, Para - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Transactions of the Royal Society of Tropical Medicine and Hygiene; v. 104, n. 8, p. 529-535, AUG 2010.
• Citações Web of Science: 18

Resumo

This prospective study was carried out from October 2003 to December 2005 and involved a cohort of 946 individuals of both genders, aged 1-89 years, from an endemic area for American visceral leishmaniasis (AVL), in Para State, Brazil. The aim of the study was to analyze the dynamics of the clinical and immunological evolution of human Leishmania ( L.) infantum chagasi infection represented by the following clinical-immunological profiles: asymptomatic infection (AI); symptomatic infection (SI = AVL); subclinical oligosymptomatic infection (SOI); subclinical resistant infection (SRI); and indeterminate initial infection (III). Infection diagnosis was determined by the indirect fluorescent antibody test and leishmanin skin test. In total, 231 cases of infection were diagnosed: the AI profile was the most frequent (73.2%), followed by SRI (12.1%), III (9.9%), SI (2.6%) and SOI (2.2%). The major conclusion regarding evolution dynamics was that the III profile plays a pivotal role from which the cases evolve to either the resistant, SRI and AI, or susceptible, SOI and SI, profiles; only one of the 23 III cases evolved to SI, while most evolved to either SRI (nine cases) or SOI (five cases) and eight cases remained as III. (C) 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 06/56319-1 - Leishmanioses no Brasil: aspectos clínicos e imunopatogenéticos da doença humana e experimental
• Beneficiário: Carlos Eduardo Pereira Corbett
• Modalidade de apoio: Auxílio à Pesquisa - Temático