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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Oral squamous cell carcinoma: status of tight junction claudins in the different histopathological patterns and relationship with clinical parameters. A tissue-microarray-based study of 136 cases

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Autor(es):
Lourenco, Silvia V. [1, 2, 3] ; Coutinho-Camillo, Claudia M. [4] ; Buim, Marcilei E. C. [4] ; Pereira, Claudia M. [4] ; Carvalho, Andre L. [5] ; Kowalski, Luiz P. [4] ; Soares, Fernando A. [1, 4]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Dent, Dept Gen Pathol, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Dermatol, Sch Med, BR-05508000 Sao Paulo - Brazil
[3] Univ Sao Paulo, Immunopathol Lab, Inst Trop Med, BR-05508000 Sao Paulo - Brazil
[4] Hosp AC Camargo Fund Antonio Prudente, Dept Surg Pathol, Sao Paulo - Brazil
[5] Hosp Canc Barretos, Dept Head & Neck Surg, Barretos - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Journal of Clinical Pathology; v. 63, n. 7, p. 609-614, JUL 2010.
Citações Web of Science: 14
Resumo

Aims Claudins are integral transmembrane proteins of the tight junctions, critical for maintaining cell adhesion and polarity. Alterations in the expression of individual claudins have been detected in carcinomas and appear to correlate with tumour progression. Methods In this study, a panel of anti-claudin antibodies (anti-claudins 1, 2, 3, 4, 5 and 7) was employed to map claudin expression in 136 cases of oral squamous cell carcinoma (OSCC) organised in a tissue microarray. Results Claudins were expressed in a reticular pattern up to the prickle layer in normal mucosal epithelium. In OSCC, claudins were strongly present in well-differentiated tumours, they presented mild and low expression in moderately differentiated OSCC, and were negative in poorly differentiated OSCC; the absences of claudin 1 (p = 0.002) and claudin 4 (p<0.001) were associated with moderately/poorly differentiated tumours. Strong expression of claudin 4 was associated with decreased perineural infiltration (p = 0.024). Claudins 5 and 7 were mostly negative or weakly expressed in all cases studied. Expression of claudin 7 was associated with the early clinical stages of the disease, whereas loss of claudin 7 tended to be more frequent in advanced stages of OSCC (p = 0.054). Absence of claudin 7 was also associated with absent vascular infiltration (p = 0.045) and with presence of recurrence (p = 0.052). Conclusions Claudin expression patterns showed a strong correlation with histological type of OSCC; claudin expression was decreased in areas of invasion, and negative in poorly differentiated tumours. This pattern may be related to evolution and prognosis of these tumours, especially in the case of claudin 7, which seems to be associated with a poor prognosis in OSCC. (AU)

Processo FAPESP: 98/14335-2 - Antonio Prudente Cancer Research Center
Beneficiário:Fernando Augusto Soares
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 06/61599-3 - Carcinoma epidermóide de cavidade oral: estudo da expressão das claudinas em 105 espécimes organizados em tissue array: correlação com marcadores de proliferação celular e com dados clínico-evolutivos dos casos
Beneficiário:Silvia Vanessa Lourenço
Modalidade de apoio: Auxílio à Pesquisa - Regular