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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oral squamous cell carcinoma: status of tight junction claudins in the different histopathological patterns and relationship with clinical parameters. A tissue-microarray-based study of 136 cases

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Author(s):
Lourenco, Silvia V. [1, 2, 3] ; Coutinho-Camillo, Claudia M. [4] ; Buim, Marcilei E. C. [4] ; Pereira, Claudia M. [4] ; Carvalho, Andre L. [5] ; Kowalski, Luiz P. [4] ; Soares, Fernando A. [1, 4]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Dent, Dept Gen Pathol, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Dermatol, Sch Med, BR-05508000 Sao Paulo - Brazil
[3] Univ Sao Paulo, Immunopathol Lab, Inst Trop Med, BR-05508000 Sao Paulo - Brazil
[4] Hosp AC Camargo Fund Antonio Prudente, Dept Surg Pathol, Sao Paulo - Brazil
[5] Hosp Canc Barretos, Dept Head & Neck Surg, Barretos - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Clinical Pathology; v. 63, n. 7, p. 609-614, JUL 2010.
Web of Science Citations: 14
Abstract

Aims Claudins are integral transmembrane proteins of the tight junctions, critical for maintaining cell adhesion and polarity. Alterations in the expression of individual claudins have been detected in carcinomas and appear to correlate with tumour progression. Methods In this study, a panel of anti-claudin antibodies (anti-claudins 1, 2, 3, 4, 5 and 7) was employed to map claudin expression in 136 cases of oral squamous cell carcinoma (OSCC) organised in a tissue microarray. Results Claudins were expressed in a reticular pattern up to the prickle layer in normal mucosal epithelium. In OSCC, claudins were strongly present in well-differentiated tumours, they presented mild and low expression in moderately differentiated OSCC, and were negative in poorly differentiated OSCC; the absences of claudin 1 (p = 0.002) and claudin 4 (p<0.001) were associated with moderately/poorly differentiated tumours. Strong expression of claudin 4 was associated with decreased perineural infiltration (p = 0.024). Claudins 5 and 7 were mostly negative or weakly expressed in all cases studied. Expression of claudin 7 was associated with the early clinical stages of the disease, whereas loss of claudin 7 tended to be more frequent in advanced stages of OSCC (p = 0.054). Absence of claudin 7 was also associated with absent vascular infiltration (p = 0.045) and with presence of recurrence (p = 0.052). Conclusions Claudin expression patterns showed a strong correlation with histological type of OSCC; claudin expression was decreased in areas of invasion, and negative in poorly differentiated tumours. This pattern may be related to evolution and prognosis of these tumours, especially in the case of claudin 7, which seems to be associated with a poor prognosis in OSCC. (AU)

FAPESP's process: 98/14335-2 - Antonio Prudente Cancer Research Center
Grantee:Fernando Augusto Soares
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC